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    NCR2 natural cytotoxicity triggering receptor 2 [ Homo sapiens (human) ]

    Gene ID: 9436, updated on 5-Nov-2017
    Official Symbol
    NCR2provided by HGNC
    Official Full Name
    natural cytotoxicity triggering receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:6732
    See related
    Ensembl:ENSG00000096264 MIM:604531; Vega:OTTHUMG00000014678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LY95; CD336; NKP44; NK-p44; dJ149M18.1
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    Location:
    6p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (41335620..41350887)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41303528..41318625)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 643, pseudogene Neighboring gene ribosomal protein L32 pseudogene 15 Neighboring gene uncharacterized LOC100505711 Neighboring gene uncharacterized LOC107986538

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
    NHGRI GWA Catalog
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    NHGRI GWA Catalog
    GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
    NHGRI GWA Catalog
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    natural cytotoxicity triggering receptor 2
    Names
    NK cell activating receptor (NKp44)
    NK cell-activating receptor
    lymphocyte antigen 95 (activating NK-receptor; NK-p44)
    lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44)
    natural killer cell p44-related protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199509.1NP_001186438.1  natural cytotoxicity triggering receptor 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional in-frame segment and an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (2) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL136967
      Consensus CDS
      CCDS56428.1
      UniProtKB/Swiss-Prot
      O95944
      Related
      ENSP00000362178.3, OTTHUMP00000016372, ENST00000373086.3, OTTHUMT00000040510
      Conserved Domains (2) summary
      cd05716
      Location:27124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:31129
      IG_like; Immunoglobulin like
    2. NM_001199510.1NP_001186439.1  natural cytotoxicity triggering receptor 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001186439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL136967
      Consensus CDS
      CCDS56429.1
      UniProtKB/Swiss-Prot
      O95944
      Related
      ENSP00000362175.4, OTTHUMP00000016371, ENST00000373083.8, OTTHUMT00000040509
      Conserved Domains (2) summary
      cd05716
      Location:27124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:31129
      IG_like; Immunoglobulin like
    3. NM_004828.3NP_004819.2  natural cytotoxicity triggering receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004819.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL136967
      Consensus CDS
      CCDS4855.1
      UniProtKB/Swiss-Prot
      O95944
      Related
      ENSP00000362181.5, OTTHUMP00000016373, ENST00000373089.9, OTTHUMT00000040511
      Conserved Domains (3) summary
      cd05716
      Location:27124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      PHA03282
      Location:93175
      PHA03282; envelope glycoprotein E; Provisional
      smart00410
      Location:31129
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      41335620..41350887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011500.1XP_016866989.1  natural cytotoxicity triggering receptor 2 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      41306785..41321882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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