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    KLF13 Kruppel like factor 13 [ Homo sapiens (human) ]

    Gene ID: 51621, updated on 12-Mar-2017
    Official Symbol
    KLF13provided by HGNC
    Official Full Name
    Kruppel like factor 13provided by HGNC
    Primary source
    HGNC:HGNC:13672
    See related
    Ensembl:ENSG00000169926 MIM:605328; Vega:OTTHUMG00000172224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTEB3; FKLF2; NSLP1; RFLAT1; RFLAT-1
    Summary
    KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
    Orthologs
    Location:
    15q13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (31326855..31435665)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (31619083..31670102)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily M member 1 Neighboring gene microRNA 211 Neighboring gene long intergenic non-protein coding RNA 2352 Neighboring gene uncharacterized LOC283710 Neighboring gene uncharacterized LOC105376707 Neighboring gene uncharacterized LOC105370939 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 4 Neighboring gene uncharacterized LOC107987220 Neighboring gene REX4 homolog, 3'-5' exonuclease pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    15q13.3 microdeletion syndrome
    MedGen: C2677613 OMIM: 612001 GeneReviews: 15q13.3 Microdeletion
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ36439, FLJ45109

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    Krueppel-like factor 13
    Names
    BTE-binding protein 3
    RANTES factor of late activated T lymphocytes-1
    basic transcription element binding protein 3
    novel Sp1-like zinc finger transcription factor 1
    transcription factor BTEB3
    transcription factor NSLP1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302461.1NP_001289390.1  Krueppel-like factor 13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF132599, AI084187, BX096457
      UniProtKB/Swiss-Prot
      Q9Y2Y9
      Conserved Domains (2) summary
      sd00017
      Location:169191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:167191
      zf-C2H2; Zinc finger, C2H2 type
    2. NM_015995.3NP_057079.2  Krueppel-like factor 13 isoform 1

      See identical proteins and their annotated locations for NP_057079.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF132599, AL390127, BC064552, BX474032
      Consensus CDS
      CCDS10025.1
      UniProtKB/Swiss-Prot
      Q9Y2Y9
      UniProtKB/TrEMBL
      X5DNR2
      Related
      ENSP00000302456, OTTHUMP00000159587, ENST00000307145, OTTHUMT00000251381
      Conserved Domains (4) summary
      COG5048
      Location:162252
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:169191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:227249
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:213236
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      31326855..31435665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p7 PATCHES

      Range
      3500227..3609057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      3612679..3721509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      31609973..31718803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033741.1: Suppressed sequence

      Description
      NR_033741.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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