Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    HOXA9 homeobox A9 [ Homo sapiens (human) ]

    Gene ID: 3205, updated on 12-Mar-2017
    Official Symbol
    HOXA9provided by HGNC
    Official Full Name
    homeobox A9provided by HGNC
    Primary source
    HGNC:HGNC:5109
    See related
    Ensembl:ENSG00000078399 MIM:142956; Vega:OTTHUMG00000023220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1; ABD-B; HOX1G; HOX1.7
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
    Orthologs
    Location:
    7p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (27162438..27165530, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27202057..27205149, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene HOXA cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene homeobox A7 Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A10

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough HOXA10-HOXA9

    Readthrough gene: HOXA10-HOXA9, Included gene: HOXA10

    Homology

    Clone Names

    • MGC1934

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    endothelial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    homeobox protein Hox-A9
    Names
    homeobox protein Hox-1G
    homeodomain protein HOXA9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029923.1 RefSeqGene

      Range
      5001..8093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152739.3NP_689952.1  homeobox protein Hox-A9

      See identical proteins and their annotated locations for NP_689952.1

      Status: REVIEWED

      Source sequence(s)
      AW612618, BC006537, BG258601, CA442923
      Consensus CDS
      CCDS5409.1
      UniProtKB/Swiss-Prot
      P31269
      Related
      ENSP00000343619, OTTHUMP00000217260, ENST00000343483, OTTHUMT00000358706
      Conserved Domains (2) summary
      pfam00046
      Location:209262
      Homeobox; Homeobox domain
      pfam04617
      Location:1193
      Hox9_act; Hox9 activation region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      27162438..27165530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      27201773..27204865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center