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    wrn.L Werner syndrome, RecQ helicase-like L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398079, updated on 29-Apr-2017
    Symbol
    wrn.L
    Full Name
    Werner syndrome, RecQ helicase-like L homeolog
    Primary source
    Xenbase:XB-GENE-992879
    Locus tag
    XELAEV_18006174mg
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    wrn; xwrn; ffa-1
    See wrn.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    100 current Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (94196796..94260423, complement)

    Chromosome 1L - NC_030724.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 8 L homeolog Neighboring gene protein phosphatase 2, catalytic subunit, beta isozyme L homeolog Neighboring gene purine-rich element binding protein G L homeolog Neighboring gene uncharacterized LOC108712238

    Genomic Sequence:
    NC_030724.1 Chromosome 1L Reference Xenopus_laevis_v2 Primary Assembly

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Preferred Names
    Werner syndrome ATP-dependent helicase homolog
    Names
    exonuclease WRN
    focus forming activity 1
    NP_001081838.1
    XP_018090070.1
    XP_018090114.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088369.1NP_001081838.1  Werner syndrome ATP-dependent helicase homolog

      See identical proteins and their annotated locations for NP_001081838.1

      Status: PROVISIONAL

      Source sequence(s)
      AF067418
      UniProtKB/Swiss-Prot
      O93530
      Conserved Domains (8) summary
      smart00341
      Location:10981177
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:479953
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd06141
      Location:55222
      WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
      smart00956
      Location:901994
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:695807
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:492653
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12091299
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:815882
      RecQ_Zn_bind; RecQ zinc-binding

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v2 Primary Assembly

    Genomic

    1. NC_030724.1 Reference Xenopus_laevis_v2 Primary Assembly

      Range
      94196796..94260423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018234625.1XP_018090114.1  Werner syndrome ATP-dependent helicase homolog isoform X2

    2. XM_018234581.1XP_018090070.1  Werner syndrome ATP-dependent helicase homolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8HWA9
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