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    Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 105243, updated on 22-Apr-2017
    Official Symbol
    Slc9a3provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3provided by MGI
    Primary source
    MGI:MGI:105064
    See related
    Ensembl:ENSMUSG00000036123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NHE3; NHE-3; AI930210; 9030624O13Rik
    Orthologs
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (74086253..74169442)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (74258963..74303512)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene Neighboring gene centrosomal protein 72 Neighboring gene predicted gene, 41003 Neighboring gene exocyst complex component 3 Neighboring gene aryl-hydrocarbon receptor repressor

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    solute:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    sodium/hydrogen exchanger 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081060.1NP_001074529.1  sodium/hydrogen exchanger 3 precursor

      See identical proteins and their annotated locations for NP_001074529.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154839
      Consensus CDS
      CCDS36731.1
      UniProtKB/Swiss-Prot
      G3X939
      Related
      ENSMUSP00000038142.6, ENSMUST00000036208.6
      Conserved Domains (3) summary
      TIGR00840
      Location:43642
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:100457
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:600672
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      74086253..74169442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517021.3XP_006517084.1  sodium/hydrogen exchanger 3 isoform X1

      Conserved Domains (3) summary
      TIGR00840
      Location:52650
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:108465
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:608680
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
    2. XM_006517022.3XP_006517085.1  sodium/hydrogen exchanger 3 isoform X2

      See identical proteins and their annotated locations for XP_006517085.1

      UniProtKB/Swiss-Prot
      G3X939
      Conserved Domains (3) summary
      TIGR00840
      Location:43642
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:100457
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam16644
      Location:600672
      NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
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