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    SFN stratifin [ Homo sapiens (human) ]

    Gene ID: 2810, updated on 19-Nov-2017
    Official Symbol
    SFNprovided by HGNC
    Official Full Name
    stratifinprovided by HGNC
    Primary source
    HGNC:HGNC:10773
    See related
    Ensembl:ENSG00000175793 MIM:601290; Vega:OTTHUMG00000004093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YWHAS
    Summary
    This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
    Orthologs
    Location:
    1p36.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (26863142..26864456)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27189633..27190947)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 165, pseudogene Neighboring gene zinc finger DHHC-type containing 18 Neighboring gene GPN-loop GTPase 2 Neighboring gene G-patch domain containing 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epidermal cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    14-3-3 protein sigma
    Names
    epithelial cell marker protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006142.4NP_006133.1  14-3-3 protein sigma

      See identical proteins and their annotated locations for NP_006133.1

      Status: REVIEWED

      Source sequence(s)
      BC001550, BC023552
      Consensus CDS
      CCDS288.1
      UniProtKB/Swiss-Prot
      P31947
      Related
      ENSP00000340989.4, OTTHUMP00000004242, ENST00000339276.5
      Conserved Domains (1) summary
      cd10019
      Location:1242
      14-3-3_sigma; 14-3-3 sigma, an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      26863142..26864456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      27302848..27304162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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