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    Sigmar1 sigma non-opioid intracellular receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18391, updated on 22-Apr-2017
    Official Symbol
    Sigmar1provided by MGI
    Official Full Name
    sigma non-opioid intracellular receptor 1provided by MGI
    Primary source
    MGI:MGI:1195268
    See related
    Ensembl:ENSMUSG00000036078 Vega:OTTMUSG00000006675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oprs1; Sig1R; sigma1R
    Summary
    This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
    Orthologs
    Location:
    4; 4 A5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (41738493..41755257, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (41685369..41688186, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene dynactin 3 Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene galactose-1-phosphate uridyl transferase Neighboring gene interleukin 11 receptor, alpha chain 1 Neighboring gene chemokine (C-C motif) ligand 27A Neighboring gene predicted gene 12407

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    opioid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lipid particle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    sigma non-opioid intracellular receptor 1
    Names
    opioid receptor, sigma 1
    sigma 1 receptor variant SR-1D
    sigma 1-type opioid receptor
    sigma1-receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286538.1NP_001273467.1  sigma non-opioid intracellular receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001273467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF030198, AY390765, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH6
      Conserved Domains (1) summary
      pfam04622
      Location:13148
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    2. NM_001286539.1NP_001273468.1  sigma non-opioid intracellular receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001273468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390764, BB741155, BB851853
      Consensus CDS
      CCDS71362.1
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      A2AMS0
      Related
      ENSMUSP00000071492.6, OTTMUSP00000007062, ENSMUST00000071561.6, OTTMUST00000015283
      Conserved Domains (1) summary
      pfam04622
      Location:13183
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    3. NM_001286540.1NP_001273469.1  sigma non-opioid intracellular receptor 1 isoform 4

      See identical proteins and their annotated locations for NP_001273469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390766, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH7
      Conserved Domains (1) summary
      pfam04622
      Location:13176
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    4. NM_001286541.1NP_001273470.1  sigma non-opioid intracellular receptor 1 isoform 5

      See identical proteins and their annotated locations for NP_001273470.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390768, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH9
      Conserved Domains (1) summary
      pfam04622
      Location:51147
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    5. NM_001286542.1NP_001273471.1  sigma non-opioid intracellular receptor 1 isoform 6

      See identical proteins and their annotated locations for NP_001273471.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded protein (isoform 6) is shorter than isoform 1.
      Source sequence(s)
      AL807796
      UniProtKB/TrEMBL
      B7ZJH8
      Conserved Domains (1) summary
      pfam04622
      Location:36105
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    6. NM_001286551.1NP_001273480.1  sigma non-opioid intracellular receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001273480.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.
      Source sequence(s)
      AF030198, BB741155, BB851853, BM507398
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      I4DCY6
      Conserved Domains (1) summary
      pfam04622
      Location:13102
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    7. NM_001286605.1NP_001273534.1  sigma non-opioid intracellular receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001273534.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. Variants 7 and 8 encode the same protein.
      Source sequence(s)
      AL807796
      UniProtKB/TrEMBL
      I4DCY6
      Conserved Domains (1) summary
      pfam04622
      Location:13102
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    8. NM_011014.3NP_035144.1  sigma non-opioid intracellular receptor 1 isoform 1

      See identical proteins and their annotated locations for NP_035144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF030198, BB741155, BB851853
      Consensus CDS
      CCDS18070.1
      UniProtKB/Swiss-Prot
      O55242
      Related
      ENSMUSP00000056027.7, OTTMUSP00000007061, ENSMUST00000059354.14, OTTMUST00000015282
      Conserved Domains (1) summary
      pfam04622
      Location:13214
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      41738493..41755257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320027.1XP_017175516.1  sigma non-opioid intracellular receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      O55242
      Conserved Domains (1) summary
      pfam04622
      Location:13214
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
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