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    CDC7 serine/threonine protein kinase CDC7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851545, updated on 9-Jul-2017
    Gene symbol
    CDC7
    Gene description
    serine/threonine protein kinase CDC7
    Primary source
    SGD:S000002175
    Locus tag
    YDL017W
    Gene type
    protein coding
    RNA name
    serine/threonine protein kinase CDC7
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LSD6; SAS1
    See CDC7 in Map Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (424209..425732)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein OSH2 Neighboring gene Erp3p Neighboring gene trans-2-enoyl-CoA reductase (NADPH) TSC13 Neighboring gene rRNA methyltransferase NOP1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of exit from mitosis IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of meiosis I IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Dbf4-dependent protein kinase complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    serine/threonine protein kinase CDC7
    NP_010267.3
    • DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of monopolin complex to kinetochores during meiosis I, regulation of meiosis-specific Ndt80p; mutation complemented by human CDC7 and DBF4 co-expression

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      424209..425732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180076.3NP_010267.3  TPA: serine/threonine protein kinase CDC7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010267.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06243
      Conserved Domains (3) summary
      smart00220
      Location:33380
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14019
      Location:31348
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:443476
      PKc_like; Protein Kinases, catalytic domain
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