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    Fgf8 fibroblast growth factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 14179, updated on 20-May-2017
    Official Symbol
    Fgf8provided by MGI
    Official Full Name
    fibroblast growth factor 8provided by MGI
    Primary source
    MGI:MGI:99604
    See related
    Ensembl:ENSMUSG00000025219 Vega:OTTMUSG00000021697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aigf; Fgf-8
    Orthologs
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (45736798..45742938, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45811288..45817374, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene RIKEN cDNA 4933429K18 gene Neighboring gene meningioma expressed antigen 5 (hyaluronidase) Neighboring gene nucleoplasmin 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC59627

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    type 1 fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 2 fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aorta morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone development ISO
    Inferred from Sequence Orthology
    more info
     
    branching involved in blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration involved in mesendoderm migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    corticotropin hormone secreting cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal/ventral axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial to mesenchymal transition involved in endocardial cushion formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial to mesenchymal transition involved in endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male genitalia development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motor neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural plate morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuroepithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    organ induction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    otic vesicle formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    otic vesicle formation TAS
    Traceable Author Statement
    more info
    PubMed 
    outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    outflow tract septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pallium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pharyngeal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    subpallium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid-stimulating hormone-secreting cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor 8
    Names
    HBGF-8
    androgen-induced growth factor
    heparin-binding growth factor 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166361.1NP_001159833.1  fibroblast growth factor 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001159833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate internal 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (2) is shorter and has a different segment in the N-terminal region, as compared to isoform 1.
      Source sequence(s)
      BC048734, BU512456
      Consensus CDS
      CCDS50452.1
      UniProtKB/TrEMBL
      Q80ZL6
      Related
      ENSMUSP00000026240.7, OTTMUSP00000024237, ENSMUST00000026240.13, OTTMUST00000051478
      Conserved Domains (1) summary
      pfam00167
      Location:81204
      FGF; Fibroblast growth factor
    2. NM_001166362.1NP_001159834.1  fibroblast growth factor 8 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001159834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate internal 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (3) is shorter and has a different segment in the N-terminal region, as compared to isoform 1.
      Source sequence(s)
      BC048734, BU512456, D12482
      Consensus CDS
      CCDS50451.1
      UniProtKB/Swiss-Prot
      P37237
      UniProtKB/TrEMBL
      Q3V279, Q80ZL6
      Related
      ENSMUSP00000107559.1, OTTMUSP00000024238, ENSMUST00000111928.7, OTTMUST00000051479
      Conserved Domains (1) summary
      pfam00167
      Location:52175
      FGF; Fibroblast growth factor
    3. NM_001166363.1NP_001159835.1  fibroblast growth factor 8 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001159835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (4) lacks an internal segment in the N-terminal region, as compared to isoform 1.
      Source sequence(s)
      BC048734, BU512456, U18673
      Consensus CDS
      CCDS50450.1
      UniProtKB/Swiss-Prot
      P37237
      UniProtKB/TrEMBL
      Q80ZL6
      Related
      ENSMUSP00000107558.1, OTTMUSP00000024239, ENSMUST00000111927.7, OTTMUST00000051480
      Conserved Domains (1) summary
      pfam00167
      Location:41164
      FGF; Fibroblast growth factor
    4. NM_010205.2NP_034335.1  fibroblast growth factor 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034335.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC048734, BU512456, D12483
      Consensus CDS
      CCDS29864.1
      UniProtKB/Swiss-Prot
      P37237
      UniProtKB/TrEMBL
      Q80ZL6
      Related
      ENSMUSP00000026241.5, OTTMUSP00000024240, ENSMUST00000026241.11, OTTMUST00000051481
      Conserved Domains (1) summary
      pfam00167
      Location:105228
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      45736798..45742938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526668.3XP_006526731.1  fibroblast growth factor 8 isoform X1

      See identical proteins and their annotated locations for XP_006526731.1

      UniProtKB/TrEMBL
      D3Z207
      Related
      ENSMUSP00000107556.1, OTTMUSP00000024242, ENSMUST00000111925.1, OTTMUST00000051483
      Conserved Domains (1) summary
      pfam00167
      Location:70193
      FGF; Fibroblast growth factor
    2. XM_011247143.1XP_011245445.1  fibroblast growth factor 8 isoform X2

      See identical proteins and their annotated locations for XP_011245445.1

      UniProtKB/TrEMBL
      D3Z208
      Related
      ENSMUSP00000107555.1, OTTMUSP00000024241, ENSMUST00000111924.7, OTTMUST00000051482
      Conserved Domains (1) summary
      pfam00167
      Location:1100
      FGF; Fibroblast growth factor
    3. XM_011247142.1XP_011245444.1  fibroblast growth factor 8 isoform X2

      See identical proteins and their annotated locations for XP_011245444.1

      UniProtKB/TrEMBL
      D3Z208
      Conserved Domains (1) summary
      pfam00167
      Location:1100
      FGF; Fibroblast growth factor
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