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    DSCR4 Down syndrome critical region 4 [ Homo sapiens (human) ]

    Gene ID: 10281, updated on 5-Nov-2017
    Official Symbol
    DSCR4provided by HGNC
    Official Full Name
    Down syndrome critical region 4provided by HGNC
    Primary source
    HGNC:HGNC:3045
    See related
    Ensembl:ENSG00000184029 MIM:604829; Vega:OTTHUMG00000086673
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCRB; DSCRB
    Summary
    The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015]
    Expression
    Low expression observed in reference dataset See more
    Location:
    21q22.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (38054011..38121360, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39426313..39493454, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily J member 6 Neighboring gene KCNJ6 antisense RNA 1 Neighboring gene uncharacterized LOC101928368 Neighboring gene Down syndrome critical region 8 (non-protein coding) Neighboring gene cutaneous T-cell lymphoma-associated antigen 1 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Other Names

    • Down syndrome critical region gene 4
    • Down syndrome critical region protein 4
    • Down syndrome critical region protein B

    Clone Names

    • AP001415.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_147130.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001410, AP001417, BU753721

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

      Range
      38054011..38121360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018932.2 Alternate CHM1_1.1

      Range
      38987663..39054402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005867.3: Suppressed sequence

      Description
      NM_005867.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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