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    SEN1 putative DNA/RNA helicase SEN1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851150, updated on 5-Mar-2017
    Gene symbol
    SEN1
    Gene description
    putative DNA/RNA helicase SEN1
    Primary source
    SGD:S000004422
    Locus tag
    YLR430W
    Gene type
    protein coding
    RNA name
    putative DNA/RNA helicase SEN1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIK3; NRD2
    See SEN1 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (993434..1000129)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mag2p Neighboring gene Crn1p Neighboring gene Atg23p Neighboring gene IMP dehydrogenase IMD3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 5'-3' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent 5'-3' DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent 5'-3' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA-dependent ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    RNA-dependent ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single-stranded DNA-dependent ATP-dependent DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent DNA replication maintenance of fidelity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-templated transcription, termination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    snRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    snoRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription-coupled nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Nrd1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    putative DNA/RNA helicase SEN1
    NP_013534.3
    • ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      993434..1000129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182318.3NP_013534.3  TPA: putative DNA/RNA helicase SEN1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013534.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00416
      Conserved Domains (4) summary
      COG1112
      Location:10061858
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam12726
      Location:106859
      SEN1_N; SEN1 N terminal
      pfam13087
      Location:16341830
      AAA_12; AAA domain
      pfam13245
      Location:13411427
      AAA_19; Part of AAA domain
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