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    DCK deoxycytidine kinase [ Homo sapiens (human) ]

    Gene ID: 1633, updated on 6-Jun-2017
    Official Symbol
    DCKprovided by HGNC
    Official Full Name
    deoxycytidine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:2704
    See related
    Ensembl:ENSG00000156136 MIM:125450; Vega:OTTHUMG00000129908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4q13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (70993548..71030914)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71859265..71896631)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene MOB kinase activator 1B Neighboring gene solute carrier family 4 member 4 Neighboring gene probable UDP-sugar transporter protein SLC35A4 Neighboring gene lactate dehydrogenase A like 6E, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117410, MGC138632

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    deoxycytidine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoside kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    deoxyribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    purine-containing compound salvage TAS
    Traceable Author Statement
    more info
     
    pyrimidine nucleoside salvage TAS
    Traceable Author Statement
    more info
     
    pyrimidine nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    deoxycytidine kinase
    Names
    deoxynucleoside kinase
    NP_000779.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023303.1 RefSeqGene

      Range
      5001..42367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000788.2NP_000779.1  deoxycytidine kinase

      See identical proteins and their annotated locations for NP_000779.1

      Status: REVIEWED

      Source sequence(s)
      BC103764, BI601939, CD014016
      Consensus CDS
      CCDS3548.1
      UniProtKB/Swiss-Prot
      P27707
      UniProtKB/TrEMBL
      F5CTF3
      Related
      ENSP00000286648.5, OTTHUMP00000160356, ENST00000286648.9, OTTHUMT00000252159
      Conserved Domains (2) summary
      TIGR00041
      Location:24240
      DTMP_kinase; dTMP kinase
      pfam01712
      Location:24258
      dNK; Deoxynucleoside kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      70993548..71030914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      71895140..71932501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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