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    TRIM23 tripartite motif containing 23 [ Homo sapiens (human) ]

    Gene ID: 373, updated on 11-May-2017
    Official Symbol
    TRIM23provided by HGNC
    Official Full Name
    tripartite motif containing 23provided by HGNC
    Primary source
    HGNC:HGNC:660
    See related
    Ensembl:ENSG00000113595 MIM:601747; Vega:OTTHUMG00000097802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARD1; ARFD1; RNF46
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (65589680..65624360, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64885507..64920187, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene centromere protein K Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene trafficking protein particle complex 13 Neighboring gene small glutamine rich tetratricopeptide repeat containing beta Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase TRIM23
    Names
    ADP-ribosylation factor domain protein 1, 64kDa
    ADP-ribosylation factor domain-containing protein 1
    ARF domain protein 1
    GTP-binding protein ARD-1
    RING finger protein 46
    RING-type E3 ubiquitin transferase TRIM23
    tripartite motif protein TRIM23
    tripartite motif-containing protein 23
    NP_001647.1
    NP_150230.1
    NP_150231.1
    XP_005248554.1
    XP_016864933.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001656.3NP_001647.1  E3 ubiquitin-protein ligase TRIM23 isoform alpha

      See identical proteins and their annotated locations for NP_001647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) encodes the longest isoform. It has a unique C-terminus compared to isoforms beta and gamma of this protein.
      Source sequence(s)
      BC022510, BI859501, L04510
      Consensus CDS
      CCDS3987.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000231524.9, OTTHUMP00000123452, ENST00000231524.13, OTTHUMT00000215058
      Conserved Domains (6) summary
      smart00502
      Location:226370
      BBC; B-Box C-terminal domain
      smart00336
      Location:173219
      BBOX; B-Box-type zinc finger
      cd04158
      Location:406574
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam00071
      Location:406565
      Ras; Ras family
      pfam13445
      Location:3173
      zf-RING_UBOX; RING-type zinc-finger
    2. NM_033227.2NP_150230.1  E3 ubiquitin-protein ligase TRIM23 isoform beta

      See identical proteins and their annotated locations for NP_150230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) is alternatively spliced near the 3' end of the coding region. This introduces a frameshift and the encoded isoform beta has a unique C-terminus compared to isoforms alpha and gamma.
      Source sequence(s)
      AF230398, BC022510, BI859501
      Consensus CDS
      CCDS43322.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000370406.3, OTTHUMP00000222562, ENST00000381018.7, OTTHUMT00000370125
      Conserved Domains (5) summary
      smart00502
      Location:226370
      BBC; B-Box C-terminal domain
      smart00336
      Location:173219
      BBOX; B-Box-type zinc finger
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:3173
      zf-RING_UBOX; RING-type zinc-finger
      cl21455
      Location:406550
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_033228.2NP_150231.1  E3 ubiquitin-protein ligase TRIM23 isoform gamma

      See identical proteins and their annotated locations for NP_150231.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) is alternatively spliced near the 3' end of the coding region. This introduces a frameshift and the encoded isoform gamma has a unique C-terminus compared to isoforms alpha and beta.
      Source sequence(s)
      AF230399, BC022510, BI859501
      Consensus CDS
      CCDS3986.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000274327.7, OTTHUMP00000123453, ENST00000274327.11, OTTHUMT00000215059
      Conserved Domains (5) summary
      smart00502
      Location:226370
      BBC; B-Box C-terminal domain
      smart00336
      Location:173219
      BBOX; B-Box-type zinc finger
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:3173
      zf-RING_UBOX; RING-type zinc-finger
      cl21455
      Location:406540
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      65589680..65624360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248497.3XP_005248554.1  E3 ubiquitin-protein ligase TRIM23 isoform X1

      Conserved Domains (4) summary
      smart00336
      Location:143
      BBOX; B-Box-type zinc finger
      cd04158
      Location:230398
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      pfam00071
      Location:230389
      Ras; Ras family
      cl23765
      Location:50194
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. XM_017009444.1XP_016864933.1  E3 ubiquitin-protein ligase TRIM23 isoform X2

      UniProtKB/Swiss-Prot
      P36406
      Conserved Domains (5) summary
      smart00502
      Location:226370
      BBC; B-Box C-terminal domain
      smart00336
      Location:173219
      BBOX; B-Box-type zinc finger
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:3173
      zf-RING_UBOX; RING-type zinc-finger
      cl21455
      Location:406550
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      64885060..64919737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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