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    BPI bactericidal/permeability-increasing protein [ Homo sapiens (human) ]

    Gene ID: 671, updated on 22-Apr-2017
    Official Symbol
    BPIprovided by HGNC
    Official Full Name
    bactericidal/permeability-increasing proteinprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000101425 MIM:109195; Vega:OTTHUMG00000032441
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    rBPI; BPIFD1
    This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
    Exon count:
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (38304150..38337503)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36932552..36965907)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transglutaminase 2 Neighboring gene uncharacterized LOC107987281 Neighboring gene KIAA1755 Neighboring gene uncharacterized LOC149684 Neighboring gene lipopolysaccharide binding protein Neighboring gene small nucleolar RNA, H/ACA box 71B Neighboring gene small nucleolar RNA host gene 17

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    NHGRI GWA Catalog
    • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
      Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    Products Interactant Other Gene Complex Source Pubs Description



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    Component Evidence Code Pubs
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    extracellular region TAS
    Traceable Author Statement
    more info
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    specific granule lumen TAS
    Traceable Author Statement
    more info
    Preferred Names
    bactericidal permeability-increasing protein
    BPI fold containing family D, member 1
    CAP 57
    recombinant BPI holoprotein, rBPI

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


    1. NG_047016.1 RefSeqGene

      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001725.2NP_001716.2  bactericidal permeability-increasing protein precursor

      See identical proteins and their annotated locations for NP_001716.2

      Status: REVIEWED

      Source sequence(s)
      AF322588, AI436120, BC032230, BP306215, DQ414688
      Consensus CDS
      ENSP00000262865.4, OTTHUMP00000030963, ENST00000262865.8, OTTHUMT00000079157
      Conserved Domains (2) summary
      BPI1; BPI/LBP/CETP N-terminal domain
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly


    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1


    1. NC_018931.2 Alternate CHM1_1.1

      GenBank, FASTA, Sequence Viewer (Graphics)
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