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    Wrn Werner syndrome RecQ like helicase [ Mus musculus (house mouse) ]

    Gene ID: 22427, updated on 25-May-2017
    Official Symbol
    Wrnprovided by MGI
    Official Full Name
    Werner syndrome RecQ like helicaseprovided by MGI
    Primary source
    MGI:MGI:109635
    See related
    Ensembl:ENSMUSG00000031583 Vega:OTTMUSG00000060957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI846146
    Orthologs
    Location:
    8 A3; 8 20.3 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (33234372..33385542, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (34344845..34495999, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33281 Neighboring gene GTP-binding protein 10 (putative) pseudogene Neighboring gene purine-rich element binding protein G Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    3'-flap-structured DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    8-hydroxy-2'-deoxyguanosine DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    bubble DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    forked DNA-dependent helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    four-way junction helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric D-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    G-quadruplex DNA unwinding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    G-quadruplex DNA unwinding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism aging ISO
    Inferred from Sequence Orthology
    more info
     
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus to nucleoplasm transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of strand invasion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to UV-C ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric D-loop disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with MutLalpha complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    Werner syndrome ATP-dependent helicase homolog
    Names
    Werner syndrome homolog
    exonuclease WRN
    NP_001116294.1
    NP_035851.3
    XP_006509154.1
    XP_006509156.1
    XP_017168151.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122822.1NP_001116294.1  Werner syndrome ATP-dependent helicase homolog

      See identical proteins and their annotated locations for NP_001116294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052466, AK162801, AK171490, BC050921
      Consensus CDS
      CCDS22229.1
      UniProtKB/Swiss-Prot
      O09053
      UniProtKB/TrEMBL
      Q3TB25, Q8BWH5
      Related
      ENSMUSP00000033991.6, ENSMUST00000033991.12
      Conserved Domains (9) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      smart00956
      Location:9231016
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:718832
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:515676
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12261316
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:837904
      RecQ_Zn_bind; RecQ zinc-binding
    2. NM_011721.4NP_035851.3  Werner syndrome ATP-dependent helicase homolog

      See identical proteins and their annotated locations for NP_035851.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052466, AK162801, AK171490, BC050921
      Consensus CDS
      CCDS22229.1
      UniProtKB/Swiss-Prot
      O09053
      UniProtKB/TrEMBL
      Q3TB25, Q8BWH5
      Related
      ENSMUSP00000033990.5, OTTMUSP00000077360, ENSMUST00000033990.6, OTTMUST00000148966
      Conserved Domains (9) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      smart00956
      Location:9231016
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:718832
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:515676
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12261316
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:837904
      RecQ_Zn_bind; RecQ zinc-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      33234372..33385542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509093.3XP_006509156.1  Werner syndrome ATP-dependent helicase homolog isoform X2

      Conserved Domains (9) summary
      smart00341
      Location:11151193
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:501974
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156343
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      smart00956
      Location:9221015
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:717831
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:514675
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12251315
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:836903
      RecQ_Zn_bind; RecQ zinc-binding
    2. XM_006509091.3XP_006509154.1  Werner syndrome ATP-dependent helicase homolog isoform X1

      See identical proteins and their annotated locations for XP_006509154.1

      UniProtKB/Swiss-Prot
      O09053
      Conserved Domains (9) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      smart00956
      Location:9231016
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:718832
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:515676
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12261316
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:837904
      RecQ_Zn_bind; RecQ zinc-binding
    3. XM_017312662.1XP_017168151.1  Werner syndrome ATP-dependent helicase homolog isoform X1

      UniProtKB/Swiss-Prot
      O09053
      Conserved Domains (9) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      smart00956
      Location:9231016
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      cd00079
      Location:718832
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:515676
      DEAD; DEAD/DEAH box helicase
      pfam14493
      Location:12261316
      HTH_40; Helix-turn-helix domain
      pfam16124
      Location:837904
      RecQ_Zn_bind; RecQ zinc-binding
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