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    MTERF1 mitochondrial transcription termination factor 1 [ Homo sapiens (human) ]

    Gene ID: 7978, updated on 6-Aug-2017
    Official Symbol
    MTERF1provided by HGNC
    Official Full Name
    mitochondrial transcription termination factor 1provided by HGNC
    Primary source
    HGNC:HGNC:21463
    See related
    Ensembl:ENSG00000127989 MIM:602318; Vega:OTTHUMG00000156057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTERF
    Summary
    This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (91872876..91880733, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91502021..91510016, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375392 Neighboring gene uncharacterized LOC107986716 Neighboring gene uncharacterized LOC101927473 Neighboring gene A-kinase anchoring protein 9 Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene cytochrome P450 family 51 subfamily A member 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC131634

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA geometric change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-templated transcription, termination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion organization TAS
    Traceable Author Statement
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    termination of mitochondrial transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    termination of mitochondrial transcription TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    transcription termination factor 1, mitochondrial
    Names
    transcription termination factor, mitochondrial

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301134.1NP_001288063.1  transcription termination factor 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001288063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK222730, AL832861, BC130391, BU740531
      Consensus CDS
      CCDS75629.1
      UniProtKB/Swiss-Prot
      Q99551
      UniProtKB/TrEMBL
      B4DPR9
      Related
      ENSP00000414116.1, OTTHUMP00000209141, ENST00000419292.1, OTTHUMT00000342895
      Conserved Domains (1) summary
      pfam02536
      Location:56369
      mTERF; mTERF
    2. NM_001301135.1NP_001288064.1  transcription termination factor 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001288064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK222730, AK298469, BU740531
      Consensus CDS
      CCDS75629.1
      UniProtKB/Swiss-Prot
      Q99551
      UniProtKB/TrEMBL
      B4DPR9
      Related
      ENSP00000384986.2, OTTHUMP00000209143, ENST00000406735.6, OTTHUMT00000342897
      Conserved Domains (1) summary
      pfam02536
      Location:56369
      mTERF; mTERF
    3. NM_006980.4NP_008911.1  transcription termination factor 1, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_008911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK222730, BC130391, BU740531
      Consensus CDS
      CCDS5621.1
      UniProtKB/Swiss-Prot
      Q99551
      Related
      ENSP00000248643.3, OTTHUMP00000209142, ENST00000351870.7, OTTHUMT00000342896
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      91872876..91880733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012620.1XP_016868109.1  transcription termination factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B4DPR9
      Conserved Domains (1) summary
      pfam02536
      Location:56369
      mTERF; mTERF
    2. XM_006716126.3XP_006716189.1  transcription termination factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006716189.1

      UniProtKB/Swiss-Prot
      Q99551
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF
    3. XM_005250593.3XP_005250650.1  transcription termination factor 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005250650.1

      UniProtKB/Swiss-Prot
      Q99551
      Conserved Domains (1) summary
      pfam02536
      Location:76389
      mTERF; mTERF

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      91432230..91440074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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