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    HSP90AA1 heat shock protein 90 alpha family class A member 1 [ Homo sapiens (human) ]

    Gene ID: 3320, updated on 25-May-2017
    Official Symbol
    HSP90AA1provided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 1provided by HGNC
    Primary source
    HGNC:HGNC:5253
    See related
    Ensembl:ENSG00000080824 MIM:140571; Vega:OTTHUMG00000171752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
    Summary
    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    14q32.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (102080738..102139749, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102547075..102606086, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene WD repeat domain 20 Neighboring gene uncharacterized LOC105370677 Neighboring gene MOK protein kinase

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
    Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
    Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection PubMed
    tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
    tat Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane PubMed
    tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
    tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

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    • Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem (from Pathway Interaction Database)
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    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
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      Signaling events mediated by VEGFR1 and VEGFR2
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, organism-specific biosystem (from REACTOME)
      Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, organism-specific biosystemTetrahydrobiopterin (BH4) is an essential co-factor for the aromatic amino acid hydroxylases and glycerol ether monooxygenase and it regulates nitric oxide synthase (NOS) activity. Inherited BH4 defi...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
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    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystem (from REACTOME)
      The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystemGTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggere...
    • Uptake and actions of bacterial toxins, organism-specific biosystem (from REACTOME)
      Uptake and actions of bacterial toxins, organism-specific biosystemThe toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of...
    • Uptake and function of diphtheria toxin, organism-specific biosystem (from REACTOME)
      Uptake and function of diphtheria toxin, organism-specific biosystemDiphtheria is a serious, often fatal human disease associated with damage to many tissues. Bacteria in infected individuals, however, are typically confined to the lining of the throat or to a skin l...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR1 specific signals, organism-specific biosystem
      VEGFR1 specific signals
    • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • eNOS activation, organism-specific biosystem (from REACTOME)
      eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
    • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
      eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...
    • vRNP Assembly, organism-specific biosystem (from REACTOME)
      vRNP Assembly, organism-specific biosystemFor each of eight gene segments, a viral ribonucleoprotein (vRNP), containing a viral negative-sense RNA (vRNA) segment complexed with nucleoprotein (NP) and the trimeric influenza polymerase (PB1, P...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ31884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    MHC class II protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TPR domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TPR domain binding TAS
    Traceable Author Statement
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ERBB2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    chaperone-mediated autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    chaperone-mediated protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body docking TAS
    Traceable Author Statement
    more info
     
    mitochondrial transport TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein refolding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization TAS
    Traceable Author Statement
    more info
     
    protein unfolding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    regulation of nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
     
    regulation of protein complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    lysosomal lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    heat shock protein HSP 90-alpha
    Names
    HSP 86
    LPS-associated protein 2
    epididymis luminal secretory protein 52
    epididymis secretory sperm binding protein Li 65p
    heat shock 86 kDa
    heat shock 90kD protein 1, alpha
    heat shock 90kD protein 1, alpha-like 4
    heat shock 90kD protein, alpha-like 4
    heat shock 90kDa protein 1, alpha
    heat shock protein 90kDa alpha (cytosolic), class A member 1
    heat shock protein 90kDa alpha family class A member 1
    lipopolysaccharide-associated protein 2
    renal carcinoma antigen NY-REN-38

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017963.2NP_001017963.2  heat shock protein HSP 90-alpha isoform 1

      See identical proteins and their annotated locations for NP_001017963.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI250920, AJ890083, BX248761, DA237149
      Consensus CDS
      CCDS32160.1
      UniProtKB/Swiss-Prot
      P07900
      UniProtKB/TrEMBL
      Q86SX1
      Related
      ENSP00000335153.7, OTTHUMP00000246767, ENST00000334701.11, OTTHUMT00000414953
      Conserved Domains (3) summary
      smart00387
      Location:162313
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:140854
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:318844
      HSP90; Hsp90 protein
    2. NM_005348.3NP_005339.3  heat shock protein HSP 90-alpha isoform 2

      See identical proteins and their annotated locations for NP_005339.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI250920, AJ890083, DC303876
      Consensus CDS
      CCDS9967.1
      UniProtKB/Swiss-Prot
      P07900
      UniProtKB/TrEMBL
      K9JA46
      Related
      ENSP00000216281.7, OTTHUMP00000246766, ENST00000216281.12, OTTHUMT00000414952
      Conserved Domains (3) summary
      smart00387
      Location:40191
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:18732
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:196722
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      102080738..102139749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536718.2XP_011535020.1  heat shock protein HSP 90-alpha isoform X1

      Conserved Domains (3) summary
      smart00387
      Location:161312
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:139853
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:317843
      HSP90; Hsp90 protein

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      102484935..102543941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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