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    ALCAM activated leukocyte cell adhesion molecule [ Homo sapiens (human) ]

    Gene ID: 214, updated on 19-May-2018
    Official Symbol
    ALCAMprovided by HGNC
    Official Full Name
    activated leukocyte cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:400
    See related
    Ensembl:ENSG00000170017 MIM:601662; Vega:OTTHUMG00000159192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEMD; CD166
    Summary
    This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in lung (RPKM 33.7), brain (RPKM 28.3) and 24 other tissues See more
    Orthologs
    See ALCAM in Genome Data Viewer
    Location:
    3q13.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (105366713..105576913)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105085557..105295757)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986108 Neighboring gene uncharacterized LOC105374023 Neighboring gene Cbl proto-oncogene B Neighboring gene uncharacterized LOC107986109 Neighboring gene uncharacterized LOC105374024

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    NHGRI GWA Catalog
    Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of activated leukocyte cell adhesion molecule (ALCAM) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ38514, MGC71733

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    focal adhesion HDA PubMed 
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029729.1 RefSeqGene

      Range
      5001..215201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243280.1NP_001230209.1  CD166 antigen isoform 2 precursor

      See identical proteins and their annotated locations for NP_001230209.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' CDS, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AC023602, AK316113, DA318514, DB541501
      Consensus CDS
      CCDS58841.1
      UniProtKB/Swiss-Prot
      Q13740
      Related
      ENSP00000419236.2, OTTHUMP00000214314, ENST00000472644.6, OTTHUMT00000353765
      Conserved Domains (5) summary
      smart00406
      Location:38113
      IGv; Immunoglobulin V-Type
      smart00410
      Location:255329
      IG_like; Immunoglobulin like
      pfam08205
      Location:137231
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:256313
      Ig_3; Immunoglobulin domain
      cl11960
      Location:415488
      Ig; Immunoglobulin domain
    2. NM_001243281.1NP_001230210.1  CD166 antigen isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a shorter and different 3' sequence, compared to variant 1. The resulting isoform (3) is truncated at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AK054632, BC029639, CA430528, DA318514
      UniProtKB/TrEMBL
      B3KNN9
      Conserved Domains (5) summary
      smart00406
      Location:38113
      IGv; Immunoglobulin V-Type
      smart00410
      Location:255329
      IG_like; Immunoglobulin like
      pfam08205
      Location:137231
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:256313
      Ig_3; Immunoglobulin domain
      cl11960
      Location:415488
      Ig; Immunoglobulin domain
    3. NM_001243283.1NP_001230212.1  CD166 antigen isoform 4 precursor

      See identical proteins and their annotated locations for NP_001230212.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' exons, and has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is the shortest; it is truncated at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AY644765, BC041127, DA318514
      UniProtKB/Swiss-Prot
      Q13740
      Conserved Domains (2) summary
      smart00406
      Location:38113
      IGv; Immunoglobulin V-Type
      smart00410
      Location:36130
      IG_like; Immunoglobulin like
    4. NM_001627.3NP_001618.2  CD166 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_001618.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC023602, AL833702, BC029639, DA318514, DB541501
      Consensus CDS
      CCDS33810.1
      UniProtKB/Swiss-Prot
      Q13740
      Related
      ENSP00000305988.5, OTTHUMP00000214313, ENST00000306107.9, OTTHUMT00000353764
      Conserved Domains (5) summary
      smart00406
      Location:38113
      IGv; Immunoglobulin V-Type
      smart00409
      Location:339393
      IG; Immunoglobulin
      pfam08205
      Location:137231
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:250313
      Ig_3; Immunoglobulin domain
      cl11960
      Location:415488
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      105366713..105576913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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