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    Casp4 caspase 4, apoptosis-related cysteine peptidase [ Mus musculus (house mouse) ]

    Gene ID: 12363, updated on 30-May-2017
    Official Symbol
    Casp4provided by MGI
    Official Full Name
    caspase 4, apoptosis-related cysteine peptidaseprovided by MGI
    Primary source
    MGI:MGI:107700
    See related
    Ensembl:ENSMUSG00000033538 Vega:OTTMUSG00000033830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Caspl; ich-3; CASP-4; Casp11; CASP-11
    Summary
    This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (5308825..5336791)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (5308860..5336791)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31429 Neighboring gene predicted gene, 31492 Neighboring gene caspase 1 Neighboring gene caspase 12 Neighboring gene phosphoglucomutase 2 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament organization TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    ectopic germ cell programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    AIM2 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NLRP3 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    caspase-4
    Names
    caspase 11, apoptosis-related cysteine peptidase
    caspase 11, apoptosis-related cysteine protease
    caspase 4, apoptosis-related cysteine protease
    caspase-11 short form splicing
    protease ICH-3
    NP_031635.2
    XP_006509900.1
    XP_006509901.1
    XP_006509902.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007609.3NP_031635.2  caspase-4 precursor

      See identical proteins and their annotated locations for NP_031635.2

      Status: REVIEWED

      Source sequence(s)
      AC141637, AK151547
      Consensus CDS
      CCDS22799.1
      UniProtKB/Swiss-Prot
      P70343
      Related
      ENSMUSP00000027012.7, OTTMUSP00000046015, ENSMUST00000027012.13, OTTMUST00000085221
      Conserved Domains (2) summary
      smart00115
      Location:122371
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:585
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      5308825..5336791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509837.2XP_006509900.1  caspase-4 isoform X1

      Conserved Domains (2) summary
      smart00115
      Location:89338
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cl14633
      Location:2452
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. XM_006509838.2XP_006509901.1  caspase-4 isoform X2

      See identical proteins and their annotated locations for XP_006509901.1

      Conserved Domains (1) summary
      smart00115
      Location:5254
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    3. XM_006509839.2XP_006509902.1  caspase-4 isoform X2

      See identical proteins and their annotated locations for XP_006509902.1

      Conserved Domains (1) summary
      smart00115
      Location:5254
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
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