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    BATF basic leucine zipper ATF-like transcription factor [ Homo sapiens (human) ]

    Gene ID: 10538, updated on 25-May-2017
    Official Symbol
    BATFprovided by HGNC
    Official Full Name
    basic leucine zipper ATF-like transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:958
    See related
    Ensembl:ENSG00000156127 MIM:612476; Vega:OTTHUMG00000171486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFA2; B-ATF; BATF1; SFA-2
    Summary
    The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    14q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (75522441..75546992)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75988784..76013335)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928377 Neighboring gene Jun dimerization protein 2 Neighboring gene uncharacterized LOC105370572 Neighboring gene uncharacterized LOC107984652 Neighboring gene uncharacterized LOC107984653 Neighboring gene uncharacterized LOC102724153 Neighboring gene feline leukemia virus subgroup C cellular receptor family member 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    NHGRI GWA Catalog
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 17 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to DNA damage stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to protozoan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lymphoid progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    myeloid dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    basic leucine zipper transcriptional factor ATF-like
    Names
    B-cell-activating transcription factor
    SF-HT-activated gene 2 protein
    activating transcription factor B
    basic leucine zipper transcription factor, ATF-like

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006399.3NP_006390.1  basic leucine zipper transcriptional factor ATF-like

      See identical proteins and their annotated locations for NP_006390.1

      Status: REVIEWED

      Source sequence(s)
      BC032294, BP235761, U15460
      Consensus CDS
      CCDS9843.1
      UniProtKB/Swiss-Prot
      Q16520
      Related
      ENSP00000286639.6, OTTHUMP00000246169, ENST00000286639.6, OTTHUMT00000413669
      Conserved Domains (1) summary
      cd14701
      Location:2683
      bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      75522441..75546992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      75926564..75951110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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