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    Lsp1 lymphocyte specific 1 [ Mus musculus (house mouse) ]

    Gene ID: 16985, updated on 22-Apr-2017
    Official Symbol
    Lsp1provided by MGI
    Official Full Name
    lymphocyte specific 1provided by MGI
    Primary source
    MGI:MGI:96832
    See related
    Ensembl:ENSMUSG00000018819 Vega:OTTMUSG00000018784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; WP34; pp52; Lsp-1
    Orthologs
    Location:
    7 F5; 7 87.93 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (142460812..142494868)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (149646775..149680504)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene synaptotagmin VIII Neighboring gene troponin I, skeletal, fast 2 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast Neighboring gene mitochondrial ribosomal protein L23

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    lymphocyte-specific protein 1
    Names
    52 kDa phosphoprotein
    S37 protein
    leukocyte specific protein 1
    lymphocyte-specific antigen WP34

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136071.2NP_001129543.1  lymphocyte-specific protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001129543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AK075783, AL603651, BX631130, S74179
      Consensus CDS
      CCDS52450.1
      UniProtKB/Swiss-Prot
      P19973
      Related
      ENSMUSP00000018963.4, OTTMUSP00000020310, ENSMUST00000018963.10, OTTMUST00000045178
      Conserved Domains (1) summary
      pfam02029
      Location:118276
      Caldesmon; Caldesmon
    2. NM_001271508.1NP_001258437.1  lymphocyte-specific protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001258437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5'-most exon, initiates translation at an alternate start codon and uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS72073.1
      UniProtKB/Swiss-Prot
      P19973
      UniProtKB/TrEMBL
      A2A6J4
      Related
      ENSMUSP00000101586.1, OTTMUSP00000020312, ENSMUST00000105966.1, OTTMUST00000045181
      Conserved Domains (1) summary
      pfam02029
      Location:116268
      Caldesmon; Caldesmon
    3. NM_001271509.1NP_001258438.1  lymphocyte-specific protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS72072.1
      UniProtKB/TrEMBL
      A2A6J7
      Related
      ENSMUSP00000101587.1, OTTMUSP00000020311, ENSMUST00000105967.7, OTTMUST00000045179
      Conserved Domains (1) summary
      pfam02029
      Location:118270
      Caldesmon; Caldesmon
    4. NM_001271510.1NP_001258439.1  lymphocyte-specific protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001258439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS52450.1
      UniProtKB/Swiss-Prot
      P19973
      Related
      ENSMUSP00000101588.1, OTTMUSP00000020314, ENSMUST00000105968.7, OTTMUST00000045189
      Conserved Domains (1) summary
      pfam02029
      Location:118276
      Caldesmon; Caldesmon
    5. NM_001271523.1NP_001258452.1  lymphocyte-specific protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001258452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate 5'-most exon, uses an alternate splice site in the 5' UTR and initiates translation at a in-frame downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK075783, BX631130
      Consensus CDS
      CCDS85469.1
      UniProtKB/TrEMBL
      A0A1B0GRF5
      Related
      ENSMUSP00000147500.1, OTTMUSP00000076624, ENSMUST00000149521.7, OTTMUST00000045180
      Conserved Domains (1) summary
      pfam02029
      Location:142
      Caldesmon; Caldesmon
    6. NM_019391.3NP_062264.1  lymphocyte-specific protein 1 isoform 2

      See identical proteins and their annotated locations for NP_062264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL603651
      Consensus CDS
      CCDS40193.1
      UniProtKB/Swiss-Prot
      P19973
      Related
      ENSMUSP00000040637.2, OTTMUSP00000020313, ENSMUST00000038946.8, OTTMUST00000045182
      Conserved Domains (1) summary
      pfam02029
      Location:116274
      Caldesmon; Caldesmon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      142460812..142494868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508494.2XP_006508557.1  lymphocyte-specific protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508557.1

      Conserved Domains (1) summary
      pfam02029
      Location:122280
      Caldesmon; Caldesmon
    2. XM_006508495.2XP_006508558.1  lymphocyte-specific protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508558.1

      Conserved Domains (1) summary
      pfam02029
      Location:122280
      Caldesmon; Caldesmon
    3. XM_006508496.2XP_006508559.1  lymphocyte-specific protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02029
      Location:122274
      Caldesmon; Caldesmon
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