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    Marcks myristoylated alanine rich protein kinase C substrate [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25603, updated on 26-Sep-2017
    Symbol
    Marcksprovided by RGD
    Full Name
    myristoylated alanine rich protein kinase C substrateprovided by RGD
    Primary source
    RGD:3028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KINC; Macs
    Summary
    protein kinase C (PKC) substrate and scaffolding protein [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 776.1), Spleen (RPKM 725.4) and 9 other tissues See more
    Orthologs
    Location:
    20q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (42966140..42971838)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (44693252..44698950)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555751 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene uncharacterized LOC102555993 Neighboring gene rCG52178-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    actin crosslink formation IEA
    Inferred from Electronic Annotation
    more info
     
    actin crosslink formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import in response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ventricular cardiac muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    actin filament bundle IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament bundle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bleb IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic branch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    germinal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    germinal vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outer dense fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    myristoylated alanine-rich C-kinase substrate
    Names
    Myristoylated alanine-rich protein kinase C substrate
    protein kinase C substrate 80 kDa protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271090.2NP_001258019.1  myristoylated alanine-rich C-kinase substrate

      Status: VALIDATED

      Source sequence(s)
      AABR07045321, M59859
      UniProtKB/TrEMBL
      F1LMW7
      Conserved Domains (1) summary
      pfam02063
      Location:2305
      MARCKS; MARCKS family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      42966140..42971838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      41434118..41439860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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