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    Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) [ Mus musculus (house mouse) ]

    Gene ID: 14800, updated on 4-Jun-2017
    Official Symbol
    Gria2provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, AMPA2 (alpha 2)provided by MGI
    Primary source
    MGI:MGI:95809
    See related
    Ensembl:ENSMUSG00000033981 Vega:OTTMUSG00000051468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GluA2; Glur2; GluR-B; Glur-2
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3 E3; 3 35.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (80682904..80803204, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (80488858..80606713, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40074 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene RIKEN cDNA A330069K06 gene Neighboring gene glycine receptor, beta subunit Neighboring gene polymerase (DNA directed), iota pseudogene Neighboring gene predicted gene, 29808

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    AMPA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular-glutamate-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ionotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    kainate selective glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutamate receptor 2
    Names
    AMPA selective glutamate receptor
    AMPA-selective glutamate receptor 2
    gluR-K2
    glutamate receptor B
    glutamate receptor ionotropic, AMPA 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039195.1NP_001034284.1  glutamate receptor 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 3' end compared to transcript variant 1, and encodes a shorter isoform (3) with a distinct C-terminus compared to isoform 1. RNA editing (CAG->CGG) changes Gln607Arg.
      Source sequence(s)
      AC163349, AK046861
      UniProtKB/Swiss-Prot
      P23819
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413764
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545764
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    2. NM_001083806.1NP_001077275.1  glutamate receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001077275.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing (CAG->CGG) changes Gln607Arg.
      Source sequence(s)
      AK045570, AK046861, AK134572, AK134647, AK163906, DN173316
      Consensus CDS
      CCDS38459.1
      UniProtKB/Swiss-Prot
      P23819
      UniProtKB/TrEMBL
      Q4LG64
      Related
      ENSMUSP00000103374.1, OTTMUSP00000069773, ENSMUST00000107745.7, OTTMUST00000130046
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    3. NM_013540.2NP_038568.2  glutamate receptor 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing (CAG->CGG) changes Gln607Arg.
      Source sequence(s)
      AC163349, AK046861, AK134572, DN173316
      Consensus CDS
      CCDS17423.1
      UniProtKB/Swiss-Prot
      P23819
      Related
      ENSMUSP00000074787.4, OTTMUSP00000069772, ENSMUST00000075316.9, OTTMUST00000130045
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      80682904..80803204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501012.3XP_006501075.1  glutamate receptor 2 isoform X1

      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    2. XM_006501013.3XP_006501076.1  glutamate receptor 2 isoform X2

      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    3. XM_006501014.2XP_006501077.1  glutamate receptor 2 isoform X3

      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545805
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    4. XM_006501015.3XP_006501078.1  glutamate receptor 2 isoform X4

      Related
      ENSMUSP00000141447.1, OTTMUSP00000069774, ENSMUST00000192463.1, OTTMUST00000130047
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413763
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545763
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region

    RNA

    1. XR_001783662.1 RNA Sequence

    2. XR_001783663.1 RNA Sequence

    3. XR_001783652.1 RNA Sequence

    4. XR_375488.2 RNA Sequence

    5. XR_375489.3 RNA Sequence

    6. XR_001783657.1 RNA Sequence

    7. XR_001783656.1 RNA Sequence

    8. XR_001783655.1 RNA Sequence

    9. XR_001783654.1 RNA Sequence

    10. XR_001783653.1 RNA Sequence

    11. XR_001783660.1 RNA Sequence

    12. XR_001783659.1 RNA Sequence

    13. XR_001783661.1 RNA Sequence

    14. XR_001783658.1 RNA Sequence

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