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    Thpo thrombopoietin [ Mus musculus (house mouse) ]

    Gene ID: 21832, updated on 25-May-2017
    Official Symbol
    Thpoprovided by MGI
    Official Full Name
    thrombopoietinprovided by MGI
    Primary source
    MGI:MGI:101875
    See related
    Ensembl:ENSMUSG00000022847 Vega:OTTMUSG00000021017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ml; Tpo; Mgdf; Mpllg
    Summary
    This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    16 B1; 16 12.51 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20724454..20734511, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20724527..20734584, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H Neighboring gene chordin Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene predicted gene 9536

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    thrombopoietin
    Names
    C-mpl ligand
    megakaryocyte colony-stimulating factor
    megakaryocyte growth and development factor
    myeloproliferative leukemia virus oncogene ligand

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173505.1NP_001166976.1  thrombopoietin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001166976.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (1, also known as Tpo1). Both variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AI314551, AK047512, CT010490
      Consensus CDS
      CCDS37292.1
      UniProtKB/Swiss-Prot
      P40226
      UniProtKB/TrEMBL
      Q543R9
      Related
      ENSMUSP00000075756.5, OTTMUSP00000023071, ENSMUST00000076422.11, OTTMUST00000049686
      Conserved Domains (1) summary
      pfam00758
      Location:25175
      EPO_TPO; Erythropoietin/thrombopoietin
    2. NM_001289894.1NP_001276823.1  thrombopoietin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 2. The resulting isoform (2, also known as Tpo2) lacks an internal 4aa peptide, compared to isoform 1.
      Source sequence(s)
      CT010490
      UniProtKB/Swiss-Prot
      P40226
      Conserved Domains (1) summary
      pfam00758
      Location:25171
      EPO_TPO; Erythropoietin/thrombopoietin
    3. NM_001289896.1NP_001276825.1  thrombopoietin isoform 3 precursor

      See identical proteins and their annotated locations for NP_001276825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region, which results in a reading frameshift, compared to variant 2. The resulting isoform (3, also known as Tpo4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      CT010490
      Conserved Domains (1) summary
      pfam00758
      Location:25119
      EPO_TPO; Erythropoietin/thrombopoietin
    4. NM_009379.3NP_033405.1  thrombopoietin isoform 1 precursor

      See identical proteins and their annotated locations for NP_033405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AK047512
      Consensus CDS
      CCDS37292.1
      UniProtKB/Swiss-Prot
      P40226
      UniProtKB/TrEMBL
      Q543R9
      Related
      ENSMUSP00000111097.2, OTTMUSP00000023070, ENSMUST00000115437.2, OTTMUST00000049685
      Conserved Domains (1) summary
      pfam00758
      Location:25175
      EPO_TPO; Erythropoietin/thrombopoietin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      20724454..20734511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316929.1XP_017172418.1  thrombopoietin isoform X4

    2. XM_017316926.1XP_017172415.1  thrombopoietin isoform X1

    3. XM_017316927.1XP_017172416.1  thrombopoietin isoform X2

    4. XM_017316928.1XP_017172417.1  thrombopoietin isoform X3

    5. XM_006521987.3XP_006522050.1  thrombopoietin isoform X7

      Conserved Domains (1) summary
      pfam00758
      Location:95245
      EPO_TPO; Erythropoietin/thrombopoietin
    6. XM_017316931.1XP_017172420.1  thrombopoietin isoform X6

    7. XM_017316934.1XP_017172423.1  thrombopoietin isoform X10

    8. XM_017316930.1XP_017172419.1  thrombopoietin isoform X5

    9. XM_017316935.1XP_017172424.1  thrombopoietin isoform X10

    10. XM_017316933.1XP_017172422.1  thrombopoietin isoform X9

    11. XM_017316932.1XP_017172421.1  thrombopoietin isoform X8

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