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    Il1rn interleukin 1 receptor antagonist [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60582, updated on 13-Mar-2018
    Official Symbol
    Il1rnprovided by RGD
    Official Full Name
    interleukin 1 receptor antagonistprovided by RGD
    Primary source
    RGD:621159
    See related
    Ensembl:ENSRNOG00000005871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IL-1ra
    Summary
    binds to IL-1 receptor, blocking the binding of IL-1 alpha and -beta [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 37.2), Lung (RPKM 29.2) and 6 other tissues See more
    Orthologs
    See Il1rn in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (1449778..1468624)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (1445598..1461452)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene interleukin 36, beta Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family member 10 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene uncharacterized LOC102549321 Neighboring gene paired box 8

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 Type I receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 Type I receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 Type II receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 Type II receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1, Type I receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1, Type I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1, Type I receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-1, Type II receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1, Type II receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acute-phase response ISO
    Inferred from Sequence Orthology
    more info
     
    carboxylic acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to norepinephrine stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chronic inflammatory response to antigenic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    fever generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fever generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to interleukin-4 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-1 receptor antagonist protein
    Names
    IL-1RN
    IL1 inhibitor
    IRAP

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022194.2NP_071530.1  interleukin-1 receptor antagonist protein precursor

      See identical proteins and their annotated locations for NP_071530.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070930, CK364274
      UniProtKB/Swiss-Prot
      P25086
      Conserved Domains (1) summary
      smart00125
      Location:34175
      IL1; Interleukin-1 homologues

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      1449778..1468624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233636.3XP_006233698.1  interleukin-1 receptor antagonist protein isoform X1

      See identical proteins and their annotated locations for XP_006233698.1

      UniProtKB/TrEMBL
      A0A0H2UHE2
      Related
      ENSRNOP00000007949.5, ENSRNOT00000007949.6
      Conserved Domains (1) summary
      smart00125
      Location:15156
      IL1; Interleukin-1 homologues
    2. XM_006233638.3XP_006233700.1  interleukin-1 receptor antagonist protein isoform X2

      See identical proteins and their annotated locations for XP_006233700.1

      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues
    3. XM_006233637.3XP_006233699.1  interleukin-1 receptor antagonist protein isoform X2

      See identical proteins and their annotated locations for XP_006233699.1

      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      1959290..1964693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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