Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    HSP104 chaperone ATPase HSP104 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850633, updated on 6-Aug-2017
    Gene symbol
    HSP104
    Gene description
    chaperone ATPase HSP104
    Primary source
    SGD:S000003949
    Locus tag
    YLL026W
    Gene type
    protein coding
    RNA name
    chaperone ATPase HSP104
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See HSP104 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (88623..91349)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Tpo1p Neighboring gene Fe-binding Fe/S cluster assembly protein ISA1 Neighboring gene tRNA Neighboring gene seripauperin PAU17

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ADP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATPase activity, coupled IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity, coupled IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    TRC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    chaperone ATPase HSP104
    NP_013074.1
    • Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      88623..91349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181846.1NP_013074.1  TPA: chaperone ATPase HSP104 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31539
      Conserved Domains (5) summary
      cd00009
      Location:187343
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR03346
      Location:7863
      chaperone_ClpB; ATP-dependent chaperone ClpB
      pfam02861
      Location:99149
      Clp_N; Clp amino terminal domain, pathogenicity island component
      pfam07724
      Location:608766
      AAA_2; AAA domain (Cdc48 subfamily)
      pfam10431
      Location:775857
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    Support Center