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    DNM1 dynamin 1 [ Homo sapiens (human) ]

    Gene ID: 1759, updated on 8-Apr-2018
    Official Symbol
    DNM1provided by HGNC
    Official Full Name
    dynamin 1provided by HGNC
    Primary source
    HGNC:HGNC:2972
    See related
    Ensembl:ENSG00000106976 MIM:602377; Vega:OTTHUMG00000020733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNM; EIEE31
    Summary
    This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 103.8) and gall bladder (RPKM 8.7) See more
    Orthologs
    Location:
    9q34.11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (128203355..128255248)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130965634..131017528)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 2 Neighboring gene chromosome 9 open reading frame 16 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene microRNA 199b Neighboring gene microRNA 3154 Neighboring gene golgin A2 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene uncharacterized LOC105376286 Neighboring gene TruB pseudouridine synthase family member 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Epileptic encephalopathy, early infantile, 31
    MedGen: C4225357 OMIM: 616346 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
    gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
      EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • Formation of annular gap junctions, organism-specific biosystem (from REACTOME)
      Formation of annular gap junctions, organism-specific biosystemGap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate w...
    • Gap junction degradation, organism-specific biosystem (from REACTOME)
      Gap junction degradation, organism-specific biosystemThe half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the...
    • Gap junction trafficking, organism-specific biosystem (from REACTOME)
      Gap junction trafficking, organism-specific biosystemGap junctions are intercellular communication channels formed from Cx (connexin) protein subunits (see Segretain and Falk 2004 and Evans et al. 2006 for comprehensive reviews). Connexins are transpor...
    • Gap junction trafficking and regulation, organism-specific biosystem (from REACTOME)
      Gap junction trafficking and regulation, organism-specific biosystemGap junctions are clusters of intercellular channels connecting adjacent cells and permitting the direct exchange of ions and small molecules between cells. These channels are composed of two hemicha...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
      Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
    • Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
      Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Synaptic Vesicle Pathway, organism-specific biosystem (from WikiPathways)
      Synaptic Vesicle Pathway, organism-specific biosystemPathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytos...
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA binding HDA PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nitric-oxide synthase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    dynamin family protein polymerization involved in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    organelle fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse structure or activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle budding from presynaptic endocytic zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendritic spine head IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular exosome HDA PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    postsynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    varicosity IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dynamin-1
    NP_001005336.1
    NP_001275666.1
    NP_001275667.1
    NP_001275668.1
    NP_004399.2
    XP_005251820.1
    XP_005251825.1
    XP_005251826.1
    XP_006717055.1
    XP_006717056.1
    XP_011516637.1
    XP_011516638.1
    XP_016869858.1
    XP_016869859.1
    XP_016869860.1
    XP_016869861.1
    XP_016869862.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029726.1 RefSeqGene

      Range
      4972..56865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005336.2NP_001005336.1  dynamin-1 isoform 2

      See identical proteins and their annotated locations for NP_001005336.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (2), also known as internal form 2 and the short C-terminal form, is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI660320, BC050279, BC063850, DA221568
      Consensus CDS
      CCDS43882.1
      UniProtKB/Swiss-Prot
      Q05193
      Related
      ENSP00000345680.7, OTTHUMP00000215499, ENST00000341179.11, OTTHUMT00000355653
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    2. NM_001288737.1NP_001275666.1  dynamin-1 isoform 3

      See identical proteins and their annotated locations for NP_001275666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, and includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AI660320, AK296326, BC050279, BC063850, DA221568, DA510154, L07810
      Consensus CDS
      CCDS75911.1
      UniProtKB/Swiss-Prot
      Q05193
      UniProtKB/TrEMBL
      B4DK06
      Related
      ENSP00000377219.3, OTTHUMP00000022237, ENST00000393594.7, OTTHUMT00000054368
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    3. NM_001288738.1NP_001275667.1  dynamin-1 isoform 3

      See identical proteins and their annotated locations for NP_001275667.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, and includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AI660320, AK316235, AL590708, BC050279, BG396820, DA221568, DA510154
      Consensus CDS
      CCDS75911.1
      UniProtKB/Swiss-Prot
      Q05193
      UniProtKB/TrEMBL
      B7ZAC0
      Related
      ENSP00000419225.1, OTTHUMP00000215498, ENST00000475805.5, OTTHUMT00000355651
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    4. NM_001288739.1NP_001275668.1  dynamin-1 isoform 4

      See identical proteins and their annotated locations for NP_001275668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is the same length as isoform 1 but differs in an internal region compared to isoform 1.
      Source sequence(s)
      AI660320, AK225179, BC050279, BC063850, DA221568, DA510154
      Consensus CDS
      CCDS75912.1
      UniProtKB/Swiss-Prot
      Q05193
      Related
      ENSP00000420045.1, OTTHUMP00000215500, ENST00000486160.3, OTTHUMT00000355654
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747844
      Atrophin-1; Atrophin-1 family
    5. NM_004408.3NP_004399.2  dynamin-1 isoform 1

      See identical proteins and their annotated locations for NP_004399.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 has been referred to as internal form 1 and the long C-terminal form.
      Source sequence(s)
      AI660320, BC050279, BC063850, DA221568
      Consensus CDS
      CCDS6895.1
      UniProtKB/Swiss-Prot
      Q05193
      Related
      ENSP00000362014.3, OTTHUMP00000022236, ENST00000372923.7, OTTHUMT00000054367
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747844
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      128203355..128255248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014371.2XP_016869860.1  dynamin-1 isoform X7

      UniProtKB/Swiss-Prot
      Q05193
      Related
      ENSP00000487310.1, OTTHUMP00000279365, ENST00000627543.2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    2. XM_005251769.3XP_005251826.1  dynamin-1 isoform X7

      See identical proteins and their annotated locations for XP_005251826.1

      UniProtKB/Swiss-Prot
      Q05193
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    3. XM_005251763.3XP_005251820.1  dynamin-1 isoform X1

      See identical proteins and their annotated locations for XP_005251820.1

      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747853
      Atrophin-1; Atrophin-1 family
    4. XM_017014369.2XP_016869858.1  dynamin-1 isoform X3

      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl26464
      Location:747852
      Atrophin-1; Atrophin-1 family
    5. XM_017014370.2XP_016869859.1  dynamin-1 isoform X4

    6. XM_011518336.3XP_011516638.1  dynamin-1 isoform X5

      See identical proteins and their annotated locations for XP_011516638.1

      UniProtKB/TrEMBL
      A0A0D9SFE4
      Related
      ENSP00000486525.1, OTTHUMP00000279313, ENST00000628346.2
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653741
      GED; Dynamin GTPase effector domain
      cl26464
      Location:743849
      Atrophin-1; Atrophin-1 family
    7. XM_005251768.3XP_005251825.1  dynamin-1 isoform X8

      See identical proteins and their annotated locations for XP_005251825.1

      UniProtKB/Swiss-Prot
      Q05193
      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl27975
      Location:752844
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    8. XM_006716992.3XP_006717055.1  dynamin-1 isoform X2

      See identical proteins and their annotated locations for XP_006717055.1

      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78604
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:520623
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      cl23807
      Location:713842
      WWbp; WW-domain ligand protein
    9. XM_011518335.3XP_011516637.1  dynamin-1 isoform X6

      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78600
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:516619
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653741
      GED; Dynamin GTPase effector domain
      cl23807
      Location:709838
      WWbp; WW-domain ligand protein
    10. XM_017014373.2XP_016869862.1  dynamin-1 isoform X11

      Conserved Domains (5) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653741
      GED; Dynamin GTPase effector domain
      cl27975
      Location:748847
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    11. XM_017014372.2XP_016869861.1  dynamin-1 isoform X9

      Conserved Domains (2) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      pfam01031
      Location:216501
      Dynamin_M; Dynamin central region
    12. XM_006716993.2XP_006717056.1  dynamin-1 isoform X10

      Conserved Domains (3) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78496
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:217498
      Dynamin_M; Dynamin central region

    RNA

    1. XR_001746219.2 RNA Sequence

    2. XR_001746220.2 RNA Sequence

    3. XR_001746222.2 RNA Sequence

    4. XR_001746221.2 RNA Sequence

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