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    SRF serum response factor [ Homo sapiens (human) ]

    Gene ID: 6722, updated on 8-Apr-2018
    Official Symbol
    SRFprovided by HGNC
    Official Full Name
    serum response factorprovided by HGNC
    Primary source
    HGNC:HGNC:11291
    See related
    Ensembl:ENSG00000112658 MIM:600589; Vega:OTTHUMG00000014722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCM1
    Summary
    This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues See more
    Orthologs
    Location:
    6p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (43171295..43181506)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43138920..43149244)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267958 Neighboring gene kinesin light chain 4 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene cullin 9 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF) PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
    Inferred from Sequence Model
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    primary miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    serum response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    angiogenesis involved in wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    bronchus cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac myofibril assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac vascular smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial structure maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    eyelid development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    face development IEA
    Inferred from Electronic Annotation
    more info
     
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart looping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart trabecula formation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    long term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lung smooth muscle development IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    megakaryocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    morphogenesis of an epithelial sheet IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    muscle cell cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of pri-miRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by glucose IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription initiation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription via serum response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    primitive streak formation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of water loss via skin IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cytokine NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance TAS
    Traceable Author Statement
    more info
    PubMed 
    sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    skin morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    tangential migration from the subventricular zone to the olfactory bulb IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    trachea cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trophectodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serum response factor
    Names
    c-fos serum response element-binding transcription factor
    minichromosome maintenance 1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001292001.1NP_001278930.1  serum response factor isoform 2

      See identical proteins and their annotated locations for NP_001278930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK300467, BC052572
      UniProtKB/Swiss-Prot
      P11831
      UniProtKB/TrEMBL
      B4DU24
    2. NM_003131.3NP_003122.1  serum response factor isoform 1

      See identical proteins and their annotated locations for NP_003122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC052572
      Consensus CDS
      CCDS4889.1
      UniProtKB/Swiss-Prot
      P11831
      UniProtKB/TrEMBL
      A0A024RD16
      Related
      ENSP00000265354.4, OTTHUMP00000016422, ENST00000265354.5, OTTHUMT00000040581
      Conserved Domains (1) summary
      cd00266
      Location:142223
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      43171295..43181506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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