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    dam DNA adenine methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947893, updated on 25-Apr-2017
    Gene symbol
    dam
    Gene description
    DNA adenine methyltransferase
    Primary source
    EcoGene:EG10204
    Locus tag
    b3387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3374; JW3350
    Summary
    Dam is a base flipping enzyme. [More information is available at EcoGene: EG10204]. DNA adenine methyltransferase (Dam), which is responsible for methylation of nearly all GATC sequences in Escherichia coli , is encoded by the dam gene and occurs at about 130 molecules per rapidly growing cell . [More information is available at EcoCyc: EG10204].
    Sequence:
    NC_000913.3 (3515077..3515913, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase Neighboring gene phosphoglycolate phosphatase Neighboring gene D-ribulose-5-phosphate 3-epimerase Neighboring gene cell division protein that binds to the septal ring Neighboring gene 3-dehydroquinate synthase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    S-adenosyl-L-methionine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site-specific DNA-methyltransferase (adenine-specific) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA methylation on adenine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bacterial-type DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mismatch repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Names
    DNA adenine methyltransferase
    NP_417846.1

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3515077..3515913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417846.1 DNA adenine methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417846.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0AEE8
      Conserved Domains (1) summary
      PRK10904
      Location:1271
      PRK10904; DNA adenine methylase; Provisional
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