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    CGA glycoprotein hormones, alpha polypeptide [ Homo sapiens (human) ]

    Gene ID: 1081, updated on 8-Oct-2017
    Official Symbol
    CGAprovided by HGNC
    Official Full Name
    glycoprotein hormones, alpha polypeptideprovided by HGNC
    Primary source
    HGNC:HGNC:1885
    See related
    Ensembl:ENSG00000135346 MIM:118850; Vega:OTTHUMG00000015161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
    Summary
    The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    6q14.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (87085498..87095147, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87795216..87804865, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1E Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene RNA, 7SK small nuclear pseudogene 209 Neighboring gene reticulocalbin 1 pseudogene 1 Neighboring gene TWIST neighbor pseudogene Neighboring gene zinc finger protein 292

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystem (from WikiPathways)
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    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
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    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
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    • GnRH signaling pathway, conserved biosystem (from KEGG)
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    • Hormone ligand-binding receptors, organism-specific biosystem (from REACTOME)
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    • Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
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      TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, organism-specific biosystemTFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is fr...
    • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
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    • Thyroxine (Thyroid Hormone) Production, organism-specific biosystem (from WikiPathways)
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    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide hormone processing TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    glycoprotein hormones alpha chain
    Names
    FSH-alpha
    LSH-alpha
    TSH-alpha
    anterior pituitary glycoprotein hormones common subunit alpha
    choriogonadotropin alpha chain
    chorionic gonadotrophin subunit alpha
    chorionic gonadotropin, alpha polypeptide
    follicle-stimulating hormone alpha chain
    follicle-stimulating hormone alpha subunit
    follitropin alpha chain
    luteinizing hormone alpha chain
    lutropin alpha chain
    thyroid-stimulating hormone alpha chain
    thyrotropin alpha chain

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000735.3NP_000726.1  glycoprotein hormones alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_000726.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI200485, BC055080, BG619154
      Consensus CDS
      CCDS5007.1
      UniProtKB/Swiss-Prot
      P01215
      UniProtKB/TrEMBL
      Q6I9S8
      Related
      ENSP00000486024.1, OTTHUMP00000016825, ENST00000627148.2, OTTHUMT00000041425
      Conserved Domains (1) summary
      pfam00236
      Location:28109
      Hormone_6; Glycoprotein hormone
    2. NM_001252383.1NP_001239312.1  glycoprotein hormones alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI200485, BC055080, BG571584, BG619154
      Consensus CDS
      CCDS75492.1
      UniProtKB/Swiss-Prot
      P01215
      UniProtKB/TrEMBL
      A0A087WYZ4
      Related
      ENSP00000482232.1, OTTHUMP00000278446, ENST00000610310.3, OTTHUMT00000481575
      Conserved Domains (1) summary
      pfam00236
      Location:60140
      Hormone_6; Glycoprotein hormone

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      87085498..87095147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      87892792..87902440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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