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    IFNA2 interferon alpha 2 [ Homo sapiens (human) ]

    Gene ID: 3440, updated on 5-Feb-2017
    Official Symbol
    IFNA2provided by HGNC
    Official Full Name
    interferon alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:5423
    See related
    Ensembl:ENSG00000188379 MIM:147562; Vega:OTTHUMG00000019674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFNA; INFA2; IFNA2B; IFN-alphaA
    Summary
    This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
    Orthologs
    Location:
    9p21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (21384255..21385397, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21384254..21385396, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon alpha 6 Neighboring gene interferon alpha 13 Neighboring gene interferon alpha 11, pseudogene Neighboring gene interferon alpha 12, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env HIV-1 gp120-mediated inhibition of IFN-alpha production involves CD4 and BDCA2 in plasmacytoid dendritic cells PubMed
    env HIV-1 gp120 inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
    env TLR-9-induced IFN-alpha production is inhibited by both monomeric and trimeric HIV-1 gp120 in plasmacytoid dendritic cells (pDC) PubMed
    env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
    env Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells PubMed
    env Interaction of HIV-1 gp120 with cell-associated CD4 leads to the induction of IFN alpha; preincubation of cells with anti-CD4 or the presence of soluble CD4 during incubation inhibits IFN alpha induction PubMed
    env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
    env HIV-1 gp120-specific cell mediated cytotoxicity (CMC) is enhanced by IL-2 or the combination of IL-2 and IFN-alpha PubMed
    env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
    Envelope surface glycoprotein gp160, precursor env IFN-alpha treated effector clones (gp120+CD8+ HPB-ALL/HIV) simultaneously downregulate CD8 expression and upregulate expression of both major histocompatibility antigen complex class I (MHC-I) and HIV-1 gp120/gp160 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef HIV-1 isolate R3A Nef mutants G2, WL58, RR106, LL165, E160NNSLL165, and DD175 fail to induce release of IFN-alpha in pDCs, suggesting that the Nef function responsible for CD4 downregulation is crucial for pDCs stimulation by R3A PubMed
    nef A highly pathogenic HIV-1 isolate R3A induces release of IFN-alpha in a Nef-dependent manner in plasmacytoid dendritic cells (pDCs) PubMed
    Pr55(Gag) gag HIV-1 Gag virus-like particles induce production of IFN-alpha in human monocyte-derived dendritic cells, which upregulates expression of APOBEC3G/F and increases incorporation of APOBEC3G/F into nascent virions PubMed
    gag Interferon alpha inhibits the release of HIV-1 Gag/capsid proteins from infected cells by inducing changes in posttranslational modifications of Gag proteins PubMed
    Tat tat HIV-1 Tat inhibits CpG-A-induced secretion of IFN-alpha and IFN-beta proteins in PBMCs PubMed
    tat HIV-1 Tat upregulates IFN-alpha secretion by macrophages, an effect that augments MIP-1alpha and MIP-1beta secretion and induces immunosuppression of uninfected T cells PubMed
    tat IFN treatment significantly reduces HIV-1 mRNA levels from a Tat defective provirus, suggesting Tat can overcome the inhibitory effects of IFN on HIV-1 replication PubMed
    tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed
    Vif vif IFN-alpha enhances APOBEC3G expression and inhibits suppression of APOBEC3G by HIV-1 Vif PubMed
    Vpr vpr Synthetic HIV-1 Vpr substantially inhibits type I IFN-alpha production by pDCs without inducing apoptosis in pDCs PubMed
    Vpu vpu IFNalpha/ribavirin treatment in vivo induces APOBEC3G, APOBEC3F, and BST-2 expression and results in hyper-mutations in viral genome and A11G/S61A mutations in HIV-1 Vpu. These two mutations in Vpu enhances the interaction between BST-2 and Vpu PubMed
    vpu IFN alpha induces retention of viral particles on the surface of fibroblasts, T cells, or primary lymphocytes infected with HIV-1 lacking the Vpu protein. HIV-1 Vpu counteracts the IFNalpha-induced retention of virus particles PubMed
    reverse transcriptase gag-pol Infection of IFN-alpha-treated primary macrophages, dendritic cells, and activated PBLs by HIV-2 and SIVmac is inhibited more potently than HIV-1 and the differential inhibition by IFN-alpha is caused by defects of vDNA accumulation by RT activity PubMed
    gag-pol IFN-alpha interferes with the initiation of HIV-1 reverse transcription resulting in a significant reduction in the relative levels of HIV-1 proviral DNA PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC125764, MGC125765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type I interferon receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T-helper 2 cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-13 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-5 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat3 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    type I interferon signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    interferon alpha-2
    Names
    IFN-alpha-2
    alpha-2a interferon
    interferon alpha 2a
    interferon alpha 2b
    interferon alpha A
    leIF A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029154.1 RefSeqGene

      Range
      5001..6143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000605.3NP_000596.2  interferon alpha-2 precursor

      See identical proteins and their annotated locations for NP_000596.2

      Status: REVIEWED

      Source sequence(s)
      AL353732, BC104163
      Consensus CDS
      CCDS6506.1
      UniProtKB/Swiss-Prot
      P01563
      Related
      ENSP00000369554, OTTHUMP00000021143, ENST00000380206, OTTHUMT00000051903
      Conserved Domains (1) summary
      pfam00143
      Location:31177
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      21384255..21385397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      21384072..21385214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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