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    SAA1 serum amyloid A1 [ Homo sapiens (human) ]

    Gene ID: 6288, updated on 12-Mar-2017
    Official Symbol
    SAA1provided by HGNC
    Official Full Name
    serum amyloid A1provided by HGNC
    Primary source
    HGNC:HGNC:10513
    See related
    Ensembl:ENSG00000173432 MIM:104750; Vega:OTTHUMG00000166147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAA; PIG4; SAA2; TP53I4
    Summary
    This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016]
    Orthologs
    Location:
    11p15.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (18266225..18269977)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18287754..18306424)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SAA2-SAA4 readthrough Neighboring gene serum amyloid A2 Neighboring gene RNA, 5S ribosomal pseudogene 333 Neighboring gene RNA, 5S ribosomal pseudogene 334 Neighboring gene ST13, Hsp70 interacting protein pseudogene 5 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene general transcription factor IIH subunit 1 Neighboring gene uncharacterized LOC105376577

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of serum amyloid A1 (SAA1) expression as compared to untreated control PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC111216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acute-phase response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    lymphocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neutrophil chemotaxis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    platelet activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cytokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-1 secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of protein secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serum amyloid A-1 protein
    Names
    serum amyloid A protein
    tumor protein p53 inducible protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021330.1 RefSeqGene

      Range
      4965..8717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000331.5NP_000322.2  serum amyloid A-1 protein preproprotein

      See identical proteins and their annotated locations for NP_000322.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BE964588, BG562565, BG565078, BX102362
      Consensus CDS
      CCDS7835.1
      UniProtKB/Swiss-Prot
      P0DJI8
      Related
      ENSP00000384906, OTTHUMP00000236629, ENST00000405158, OTTHUMT00000395864
      Conserved Domains (1) summary
      pfam00277
      Location:23122
      SAA; Serum amyloid A protein
    2. NM_001178006.2NP_001171477.1  serum amyloid A-1 protein preproprotein

      See identical proteins and their annotated locations for NP_001171477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC105796, BE964588, BG562565, BX102362
      Consensus CDS
      CCDS7835.1
      UniProtKB/Swiss-Prot
      P0DJI8
      Related
      ENSP00000436866, OTTHUMP00000232000, ENST00000532858, OTTHUMT00000388079
      Conserved Domains (1) summary
      pfam00277
      Location:23122
      SAA; Serum amyloid A protein
    3. NM_199161.4NP_954630.1  serum amyloid A-1 protein preproprotein

      See identical proteins and their annotated locations for NP_954630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC007022, BE964588, BG562565, BX102362
      Consensus CDS
      CCDS7835.1
      UniProtKB/Swiss-Prot
      P0DJI8
      Related
      ENSP00000348918, OTTHUMP00000232001, ENST00000356524, OTTHUMT00000388080
      Conserved Domains (1) summary
      pfam00277
      Location:23122
      SAA; Serum amyloid A protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      18266225..18269977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      18287225..18290997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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