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    NR2C1 nuclear receptor subfamily 2 group C member 1 [ Homo sapiens (human) ]

    Gene ID: 7181, updated on 22-Apr-2017
    Official Symbol
    NR2C1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 2 group C member 1provided by HGNC
    Primary source
    HGNC:HGNC:7971
    See related
    Ensembl:ENSG00000120798 MIM:601529; Vega:OTTHUMG00000170131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR2
    Summary
    This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (95020229..95073628, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95414005..95467404, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369915 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene ribosomal protein L14 pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA upregulates NR2C1 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    nuclear receptor subfamily 2 group C member 1
    Names
    TR2 nuclear hormone receptor
    nuclear receptor subfamily 2, group C isoform
    orphan nuclear receptor TR2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032287.2NP_001027458.1  nuclear receptor subfamily 2 group C member 1 isoform b

      See identical proteins and their annotated locations for NP_001027458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (b, also known as TR2-9) has a shorter C-terminus compared to isoform a.
      Source sequence(s)
      BC040141, DB266298
      Consensus CDS
      CCDS41821.1
      UniProtKB/Swiss-Prot
      P13056
      UniProtKB/TrEMBL
      H9NIM3
      Related
      ENSP00000376813.3, OTTHUMP00000243015, ENST00000393101.7, OTTHUMT00000407572
      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368464
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001127362.1NP_001120834.1  nuclear receptor subfamily 2 group C member 1 isoform c

      See identical proteins and their annotated locations for NP_001120834.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (c, also known as TR2-5) has a shorter C-terminus compared to isoform a.
      Source sequence(s)
      AK291319, BC040141, DB266298, M21985
      Consensus CDS
      CCDS44953.1
      UniProtKB/Swiss-Prot
      P13056
      Related
      ENSP00000328843.7, OTTHUMP00000243016, ENST00000330677.7, OTTHUMT00000407573
      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368465
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. NM_003297.3NP_003288.2  nuclear receptor subfamily 2 group C member 1 isoform a

      See identical proteins and their annotated locations for NP_003288.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as TR2-11).
      Source sequence(s)
      AC011598, AK291319, DB266298, JQ308177
      Consensus CDS
      CCDS9051.1
      UniProtKB/Swiss-Prot
      P13056
      UniProtKB/TrEMBL
      H9NIM2
      Related
      ENSP00000333275.4, OTTHUMP00000243013, ENST00000333003.9, OTTHUMT00000407565
      Conserved Domains (2) summary
      cd06952
      Location:368589
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      95020229..95073628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538717.2XP_011537019.1  nuclear receptor subfamily 2 group C member 1 isoform X4

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:322493
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_006719584.2XP_006719647.1  nuclear receptor subfamily 2 group C member 1 isoform X2

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368543
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. XM_005269133.2XP_005269190.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      Conserved Domains (2) summary
      cd06952
      Location:368584
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    4. XM_011538716.2XP_011537018.1  nuclear receptor subfamily 2 group C member 1 isoform X3

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368514
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_006719585.2XP_006719648.1  nuclear receptor subfamily 2 group C member 1 isoform X5

      Conserved Domains (2) summary
      cd06952
      Location:191412
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:117
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RNA

    1. XR_001748864.1 RNA Sequence

    2. XR_944699.2 RNA Sequence

    3. XR_429114.2 RNA Sequence

    4. XR_001748861.1 RNA Sequence

    5. XR_001748863.1 RNA Sequence

    6. XR_001748862.1 RNA Sequence

    7. XR_944700.1 RNA Sequence

    8. XR_245956.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      95378558..95432374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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