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    Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [ Mus musculus (house mouse) ]

    Gene ID: 16149, updated on 1-Oct-2017
    Official Symbol
    Cd74provided by MGI
    Official Full Name
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)provided by MGI
    Primary source
    MGI:MGI:96534
    See related
    Ensembl:ENSMUSG00000024610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
    Orthologs
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (60803849..60812652)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (60963503..60972306)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S16 pseudogene Neighboring gene ribosomal protein S14 Neighboring gene microRNA 5107 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene predicted gene, 41744

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    MHC class II protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    MHC class II protein binding, via antigen binding groove ISO
    Inferred from Sequence Orthology
    more info
     
    MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone mediated protein folding requiring cofactor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone mediated protein folding requiring cofactor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macrophage migration inhibitory factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mature B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of innate immune response IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOS2-CD74 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    macrophage migration inhibitory factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    macrophage migration inhibitory factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vacuole ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    H-2 class II histocompatibility antigen gamma chain
    Names
    HLA-DR-GAMMA
    Ia-associated invariant chain
    MHC class II-associated invariant chain
    class II-associated invariant chain peptide
    dinucleotide microsatellite
    histocompatibility: class II antigens, gamma chain of
    ia antigen-associated invariant chain
    invariant polypeptide of major histocompatibility complex, class II antigen-associated

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042605.1NP_001036070.1  H-2 class II histocompatibility antigen gamma chain isoform 1

      See identical proteins and their annotated locations for NP_001036070.1

      Status: VALIDATED

      Source sequence(s)
      AK002232, AW123644, BG148172
      Consensus CDS
      CCDS37835.1
      UniProtKB/Swiss-Prot
      P04441
      UniProtKB/TrEMBL
      Q3U4Q8, Q545Y5
      Related
      ENSMUSP00000095171.2, ENSMUST00000097563.8
      Conserved Domains (3) summary
      cd00191
      Location:195254
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam08831
      Location:119184
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:1111
      MHC2-interact; CLIP, MHC2 interacting
    2. NM_010545.3NP_034675.1  H-2 class II histocompatibility antigen gamma chain isoform 2

      See identical proteins and their annotated locations for NP_034675.1

      Status: VALIDATED

      Source sequence(s)
      AK002232, AW123644
      Consensus CDS
      CCDS50299.1
      UniProtKB/TrEMBL
      Q545Y5
      Related
      ENSMUSP00000057836.8, ENSMUST00000050487.14
      Conserved Domains (2) summary
      pfam08831
      Location:119184
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:1111
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      60803849..60812652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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