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    Map2k3 mitogen-activated protein kinase kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 26397, updated on 21-May-2017
    Official Symbol
    Map2k3provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase 3provided by MGI
    Primary source
    MGI:MGI:1346868
    See related
    Ensembl:ENSMUSG00000018932 Vega:OTTMUSG00000006341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MEK3; MKK3; Prkmk3; mMKK3b; AW212142
    Orthologs
    Location:
    11; 11 B2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (60932057..60952803)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60745559..60766305)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39830 Neighboring gene mitogen-activated protein kinase kinase 3, opposite strand Neighboring gene predicted gene, 35681 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene predicted gene, 46283

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cytokine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 3
    Names
    MAP kinase kinase 3
    MAPK/ERK kinase 3
    MAPKK 3
    MEK 3
    protein kinase, mitogen-activated, kinase 3
    NP_032954.1
    XP_006533431.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008928.4NP_032954.1  dual specificity mitogen-activated protein kinase kinase 3

      See identical proteins and their annotated locations for NP_032954.1

      Status: PROVISIONAL

      Source sequence(s)
      AL603830
      Consensus CDS
      CCDS24804.1
      UniProtKB/Swiss-Prot
      O09110
      UniProtKB/TrEMBL
      Q5SWN9
      Related
      ENSMUSP00000019076.3, OTTMUSP00000006687, ENSMUST00000019076.9, OTTMUST00000014413
      Conserved Domains (2) summary
      cd06617
      Location:62344
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
      smart00220
      Location:67325
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      60932057..60952803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533368.3XP_006533431.1  dual specificity mitogen-activated protein kinase kinase 3 isoform X1

      Conserved Domains (2) summary
      cd06617
      Location:1255
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
      smart00220
      Location:1236
      S_TKc; Serine/Threonine protein kinases, catalytic domain
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