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    Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 19017, updated on 27-Mar-2017
    Official Symbol
    Ppargc1aprovided by MGI
    Official Full Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
    Primary source
    MGI:MGI:1342774
    See related
    Ensembl:ENSMUSG00000029167 Vega:OTTMUSG00000022759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha
    Summary
    This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    5; 5 C1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (51454249..52116058, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (51845488..51945160, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40319 Neighboring gene predicted gene, 29924 Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription cofactor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-dependent nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-dependent nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ligand-dependent nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fatty acid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glomerular visceral epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to dietary excess IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muscle activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muscle activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    interfibrillar mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    subsarcolemmal mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Names
    PPAR-gamma coactivator 1-alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008904.2NP_032930.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha

      See identical proteins and their annotated locations for NP_032930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC116763, AK138668
      Consensus CDS
      CCDS19282.1
      UniProtKB/Swiss-Prot
      O70343
      Related
      ENSMUSP00000117040, OTTMUSP00000026095, ENSMUST00000132734, OTTMUST00000054635
      Conserved Domains (1) summary
      cd12623
      Location:674764
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

    RNA

    1. NR_027710.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB061324, AC116763, AK138668
    2. NR_132764.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate first exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC116763, BB853729, JX866948

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      51454249..52116058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503774.3XP_006503837.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1

      Conserved Domains (1) summary
      cd12623
      Location:687777
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    2. XM_006503776.3XP_006503839.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3

      Conserved Domains (1) summary
      cd12623
      Location:664754
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    3. XM_017320717.1XP_017176206.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

    4. XM_006503775.1XP_006503838.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

      Conserved Domains (1) summary
      cd12623
      Location:670760
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    5. XM_006503777.3XP_006503840.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

      Conserved Domains (1) summary
      cd12623
      Location:661751
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    6. XM_017320716.1XP_017176205.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

    7. XM_006503778.3XP_006503841.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

      Conserved Domains (1) summary
      cd12623
      Location:659749
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    8. XM_017320718.1XP_017176207.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

    9. XM_006503779.3XP_006503842.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X7

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