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    MAT1A methionine adenosyltransferase 1A [ Homo sapiens (human) ]

    Gene ID: 4143, updated on 25-May-2017
    Official Symbol
    MAT1Aprovided by HGNC
    Official Full Name
    methionine adenosyltransferase 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:6903
    See related
    Ensembl:ENSG00000151224 MIM:610550; Vega:OTTHUMG00000018613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAT; SAMS; MATA1; SAMS1
    Summary
    This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q22.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (80271820..80290003, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82031576..82049721, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2 Neighboring gene uncharacterized LOC100130698 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 4 Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene DPY30 domain containing 1 Neighboring gene DPY30 domain containing 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methionine adenosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methionine adenosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    selenomethionine adenosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methionine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylation TAS
    Traceable Author Statement
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    selenium compound metabolic process TAS
    Traceable Author Statement
    more info
     
    sulfur amino acid metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase
    Names
    MAT 1
    MAT-I/III
    S-adenosylmethionine synthetase isoform type-1
    adoMet synthase 1
    adoMet synthetase 1
    methionine adenosyltransferase 1
    methionine adenosyltransferase I, alpha
    methionine adenosyltransferase I/III
    NP_000420.1
    XP_005269899.1
    XP_005269900.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008083.1 RefSeqGene

      Range
      5001..22859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000429.2NP_000420.1  S-adenosylmethionine synthase isoform type-1

      See identical proteins and their annotated locations for NP_000420.1

      Status: REVIEWED

      Source sequence(s)
      BC018359, BM738684, BX496326, X69078
      Consensus CDS
      CCDS7365.1
      UniProtKB/Swiss-Prot
      Q00266
      Related
      ENSP00000361287.3, OTTHUMP00000019971, ENST00000372213.7, OTTHUMT00000049070
      Conserved Domains (4) summary
      PTZ00104
      Location:12393
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:18114
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:129250
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:252388
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      80271820..80290003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269843.4XP_005269900.1  S-adenosylmethionine synthase isoform X2

      See identical proteins and their annotated locations for XP_005269900.1

      Conserved Domains (4) summary
      PTZ00104
      Location:12352
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:1873
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:88209
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:211347
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
    2. XM_005269842.4XP_005269899.1  S-adenosylmethionine synthase isoform X1

      See identical proteins and their annotated locations for XP_005269899.1

      UniProtKB/Swiss-Prot
      Q00266
      Conserved Domains (4) summary
      PTZ00104
      Location:12393
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:18114
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:129250
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:252388
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      82314612..82332492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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