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    ERVW-1 endogenous retrovirus group W member 1, envelope [ Homo sapiens (human) ]

    Gene ID: 30816, updated on 6-Sep-2017
    Official Symbol
    ERVW-1provided by HGNC
    Official Full Name
    endogenous retrovirus group W member 1, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:13525
    See related
    Ensembl:ENSG00000242950 MIM:604659; Vega:OTTHUMG00000131249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
    Summary
    Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    7q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (92468380..92477915, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (92097694..92107229, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 7, pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 1 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene peroxisomal biogenesis factor 1 Neighboring gene RNA binding motif protein 48

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-mediated regulation of MSRV and Syncytin-1 involves TLR-4 in primary astrocytes PubMed
    tat HIV-1 Tat stimulates MSRV and inhibits Syncytin-1 in monocytes, while in primary astrocytes and differentiated macrophages Tat stimulates both MSRV and Syncytin-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syncytium formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syncytium formation by plasma membrane fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    viral envelope IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    syncytin-1
    Names
    HERV-7q envelope protein
    HERV-W Env glycoprotein
    HERV-W envelope protein
    HERV-W_7q21.2 provirus ancestral Env polyprotein
    HERV-tryptophan envelope protein
    endogenous retroviral family W, env(C7), member 1
    endogenous retrovirus group W member 1
    envelope glycoprotein
    envelope polyprotein gPr73
    enverin
    human endogenous retrovirus W envC7-1 envelope protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130925.1NP_001124397.1  syncytin-1 precursor

      See identical proteins and their annotated locations for NP_001124397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF072506, BC137381
      Consensus CDS
      CCDS5626.1
      UniProtKB/Swiss-Prot
      Q9UQF0
      UniProtKB/TrEMBL
      D0EYG5
      Related
      ENSP00000474984.1, OTTHUMP00000272562, ENST00000603053.1, OTTHUMT00000468284
      Conserved Domains (1) summary
      pfam00429
      Location:22477
      TLV_coat; ENV polyprotein (coat polyprotein)
    2. NM_014590.3NP_055405.3  syncytin-1 precursor

      See identical proteins and their annotated locations for NP_055405.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, unspliced transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF208161, BG012022, BX365066, BX391741
      Consensus CDS
      CCDS5626.1
      UniProtKB/Swiss-Prot
      Q9UQF0
      UniProtKB/TrEMBL
      D0EYG5
      Related
      ENSP00000419945.1, OTTHUMP00000161914, ENST00000493463.2, OTTHUMT00000254009
      Conserved Domains (1) summary
      pfam00429
      Location:22477
      TLV_coat; ENV polyprotein (coat polyprotein)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      92468380..92477915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      92027730..92037265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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