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    Tbx21 T-box 21 [ Mus musculus (house mouse) ]

    Gene ID: 57765, updated on 15-Feb-2017
    Official Symbol
    Tbx21provided by MGI
    Official Full Name
    T-box 21provided by MGI
    Primary source
    MGI:MGI:1888984
    See related
    Ensembl:ENSMUSG00000001444 Vega:OTTMUSG00000002233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TBT1; Tbet; Tblym
    Orthologs
    Location:
    11; 11 D
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (97098007..97115331, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96959321..96976645, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene oxysterol binding protein-like 7 Neighboring gene microRNA 8103 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene karyopherin (importin) beta 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
      Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
      Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lymphocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    T-box transcription factor TBX21
    Names
    T-box protein 21
    T-cell-specific T-box transcription factor T-bet
    transcription factor TBLYM

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019507.2NP_062380.2  T-box transcription factor TBX21

      See identical proteins and their annotated locations for NP_062380.2

      Status: VALIDATED

      Source sequence(s)
      AK054495, AL627445, BC137986
      Consensus CDS
      CCDS25315.1
      UniProtKB/Swiss-Prot
      Q9JKD8
      UniProtKB/TrEMBL
      Q3U150
      Related
      ENSMUSP00000001484, OTTMUSP00000002150, ENSMUST00000001484, OTTMUST00000004472
      Conserved Domains (2) summary
      pfam00907
      Location:138325
      T-box; T-box
      pfam16176
      Location:393520
      T-box_assoc; T-box transcription factor-associated

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      97098007..97115331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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