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    TREM2 triggering receptor expressed on myeloid cells 2 [ Homo sapiens (human) ]

    Gene ID: 54209, updated on 28-May-2017
    Official Symbol
    TREM2provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells 2provided by HGNC
    Primary source
    HGNC:HGNC:17761
    See related
    Ensembl:ENSG00000095970 MIM:605086; Vega:OTTHUMG00000014671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TREM-2; Trem2a; Trem2b; Trem2c
    Summary
    This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
    Orthologs
    Location:
    6p21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (41158506..41163200, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41126244..41130924, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene adenylate cyclase 10, soluble pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells like 1 Neighboring gene uncharacterized LOC107986595 Neighboring gene triggering receptor expressed on myeloid cells like 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    NHGRI GWA Catalog
    Variant of TREM2 associated with the risk of Alzheimer's disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
      Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipoteichoic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    detection of lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    detection of peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
     
    phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of C-C chemokine receptor CCR7 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of CD40 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    triggering receptor expressed on myeloid cells 2
    Names
    triggering receptor expressed on monocytes 2
    triggering receptor expressed on myeloid cells 2a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011561.1 RefSeqGene

      Range
      4999..9679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_631

    mRNA and Protein(s)

    1. NM_001271821.1NP_001258750.1  triggering receptor expressed on myeloid cells 2 precursor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), alternately referred to as TREM-2V, lacks a 3' coding exon which results in a frameshift, compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AB062787, BC032362
      Consensus CDS
      CCDS64422.1
      UniProtKB/Swiss-Prot
      Q9NZC2
      Related
      ENSP00000342651.4, OTTHUMP00000016369, ENST00000338469.3, OTTHUMT00000040500
      Conserved Domains (2) summary
      smart00410
      Location:26111
      IG_like; Immunoglobulin like
      cl11960
      Location:23128
      Ig; Immunoglobulin domain
    2. NM_018965.3NP_061838.1  triggering receptor expressed on myeloid cells 2 precursor isoform 1 precursor

      See identical proteins and their annotated locations for NP_061838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB062787, AF213457, BC032362
      Consensus CDS
      CCDS4852.1
      UniProtKB/Swiss-Prot
      Q9NZC2
      UniProtKB/TrEMBL
      Q5TCX1
      Related
      ENSP00000362205.3, OTTHUMP00000016368, ENST00000373113.7, OTTHUMT00000040499
      Conserved Domains (2) summary
      smart00410
      Location:26111
      IG_like; Immunoglobulin like
      cl11960
      Location:23128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      41158506..41163200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715116.3XP_006715179.1  triggering receptor expressed on myeloid cells 2 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      41129139..41133819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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