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    Adcy3 adenylate cyclase 3 [ Mus musculus (house mouse) ]

    Gene ID: 104111, updated on 7-Feb-2017
    Official Symbol
    Adcy3provided by MGI
    Official Full Name
    adenylate cyclase 3provided by MGI
    Primary source
    MGI:MGI:99675
    See related
    Ensembl:ENSMUSG00000020654 Vega:OTTMUSG00000033731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AC3; mKIAA0511
    Orthologs
    Location:
    12; 12 A1.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (4132996..4213525)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (4133397..4213524)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene EFR3 homolog B Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene predicted gene, 31794 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium- and calmodulin-responsive adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to forskolin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    adenylate cyclase type 3
    Names
    AC-III
    ATP pyrophosphate-lyase 3
    adenylate cyclase type III
    adenylate cyclase, olfactive type
    adenylyl cyclase 3
    NP_001153008.1
    NP_001153009.1
    NP_612178.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159536.1NP_001153008.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q80TY9
      Related
      ENSMUSP00000122073, OTTMUSP00000045854, ENSMUST00000124505, OTTMUST00000084969
      Conserved Domains (3) summary
      smart00044
      Location:8831101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9141121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. NM_001159537.1NP_001153009.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q80TY9
      Related
      ENSMUSP00000115644, OTTMUSP00000045855, ENSMUST00000152065, OTTMUST00000084970
      Conserved Domains (3) summary
      smart00044
      Location:8831101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9141121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    3. NM_138305.3NP_612178.2  adenylate cyclase type 3 isoform 1

      See identical proteins and their annotated locations for NP_612178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK122298, BQ442923
      Consensus CDS
      CCDS25787.1
      UniProtKB/Swiss-Prot
      Q8VHH7
      UniProtKB/TrEMBL
      Q80TY9
      Related
      ENSMUSP00000020984, ENSMUST00000020984
      Conserved Domains (3) summary
      smart00044
      Location:8841102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      4132996..4213525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514932.2XP_006514995.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514995.1

      UniProtKB/Swiss-Prot
      Q8VHH7
      Conserved Domains (3) summary
      smart00044
      Location:8841102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. XM_006514933.2XP_006514996.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514996.1

      UniProtKB/Swiss-Prot
      Q8VHH7
      Conserved Domains (3) summary
      smart00044
      Location:8841102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    3. XM_006514935.3XP_006514998.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514998.1

      UniProtKB/Swiss-Prot
      Q8VHH7
      Related
      ENSMUSP00000115406, OTTMUSP00000045856, ENSMUST00000127756, OTTMUST00000084971
      Conserved Domains (3) summary
      smart00044
      Location:8841102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    4. XM_006514934.3XP_006514997.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514997.1

      UniProtKB/Swiss-Prot
      Q8VHH7
      Conserved Domains (3) summary
      smart00044
      Location:8841102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
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