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    Rtn4r reticulon 4 receptor [ Mus musculus (house mouse) ]

    Gene ID: 65079, updated on 18-Mar-2017
    Official Symbol
    Rtn4rprovided by MGI
    Official Full Name
    reticulon 4 receptorprovided by MGI
    Primary source
    MGI:MGI:2136886
    See related
    Ensembl:ENSMUSG00000043811 Vega:OTTMUSG00000036604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NgR; NgR1; NOGOR
    Orthologs
    Location:
    16; 16 A3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18127706..18152408)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18127799..18152501)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene proline dehydrogenase Neighboring gene microRNA 6366 Neighboring gene predicted gene, 34679

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chondroitin sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ganglioside GM1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    ganglioside GT1b binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuregulin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuronal signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    reticulon-4 receptor
    Names
    Nogo-66 receptor
    nogo receptor
    nogo receptor; Nogo-66 receptor
    nogo66 receptor-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022982.2NP_075358.1  reticulon-4 receptor precursor

      See identical proteins and their annotated locations for NP_075358.1

      Status: PROVISIONAL

      Source sequence(s)
      AF283462
      Consensus CDS
      CCDS37279.1
      UniProtKB/Swiss-Prot
      Q99PI8
      Related
      ENSMUSP00000062924, OTTMUSP00000052148, ENSMUST00000059589, OTTMUST00000093843
      Conserved Domains (4) summary
      cd00116
      Location:90166
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6082
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:156195
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131190
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      18127706..18152408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_187007.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      385195..410057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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