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    Trp63 transformation related protein 63 [ Mus musculus (house mouse) ]

    Gene ID: 22061, updated on 17-Oct-2017
    Official Symbol
    Trp63provided by MGI
    Official Full Name
    transformation related protein 63provided by MGI
    Primary source
    MGI:MGI:1330810
    See related
    Ensembl:ENSMUSG00000022510 Vega:OTTMUSG00000021015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ket; P63; P73l; Tp63; P51/P63; AI462811; Trp53rp1
    Summary
    This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
    Orthologs
    Location:
    16 B1; 16 17.37 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (25683763..25892088)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (25683851..25892174)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H2 pseudogene Neighboring gene UPF0568 protein C14orf166 homolog Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene predicted gene, 41436

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (19)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC115972

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    anatomical structure formation involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cloacal septation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    ectoderm and mesoderm interaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of planar polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic G1 DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    morphogenesis of a polarized epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of keratinocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polarized epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostatic bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epidermal cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    replicative cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to gamma radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    urinary bladder development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127259.1NP_001120731.1  tumor protein 63 isoform a

      See identical proteins and their annotated locations for NP_001120731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TAp63alpha).
      Source sequence(s)
      AF075436, AK138305, BC090649
      Consensus CDS
      CCDS49809.1
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q5CZX0
      Related
      ENSMUSP00000110965.2, OTTMUSP00000023061, ENSMUST00000115310.8, OTTMUST00000049678
      Conserved Domains (4) summary
      cd09572
      Location:543607
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:392431
      P53_tetramer; P53 tetramerisation motif
      pfam08430
      Location:452535
      Forkhead_N; Forkhead N-terminal region
    2. NM_001127260.1NP_001120732.1  tumor protein 63 isoform b

      See identical proteins and their annotated locations for NP_001120732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TAp63beta) has a shorter and different C-terminus, as compared to isoform a.
      Source sequence(s)
      AF075435, AK138305, BC090649
      Consensus CDS
      CCDS49810.1
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q5CZX0
      Related
      ENSMUSP00000067005.5, ENSMUST00000065523.11
      Conserved Domains (2) summary
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:392431
      P53_tetramer; P53 tetramerisation motif
    3. NM_001127261.1NP_001120733.1  tumor protein 63 isoform c

      See identical proteins and their annotated locations for NP_001120733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal 12 nt segment and several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TAp63gamma) lacks internal 4 aa and has a shorter and different C-terminus, as compared to isoform a.
      Source sequence(s)
      AF075434, AK138305, AK140023, BC092537
      Consensus CDS
      CCDS49808.1
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q569E5
      Related
      ENSMUSP00000110963.2, ENSMUST00000115308.8
      Conserved Domains (2) summary
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:388427
      P53_tetramer; P53 tetramerisation motif
    4. NM_001127262.1NP_001120734.1  tumor protein 63 isoform f

      See identical proteins and their annotated locations for NP_001120734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (f, also known as DNp63beta) has shorter and different N- and C-termini, as compared to isoform a.
      Source sequence(s)
      AF075438, AK048623, BC090649
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q5CZX0
      Conserved Domains (2) summary
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:298337
      P53_tetramer; P53 tetramerisation motif
    5. NM_001127263.1NP_001120735.1  tumor protein 63 isoform g

      See identical proteins and their annotated locations for NP_001120735.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (g, also known as DNp63gamma) has shorter and different N- and C-termini, as compared to isoform a.
      Source sequence(s)
      AK140023, BC092537
      Consensus CDS
      CCDS49812.1
      UniProtKB/TrEMBL
      Q569E5
      Related
      ENSMUSP00000110960.1, OTTMUSP00000023064, ENSMUST00000115305.1, OTTMUST00000049681
      Conserved Domains (2) summary
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:298337
      P53_tetramer; P53 tetramerisation motif
    6. NM_001127264.1NP_001120736.1  tumor protein 63 isoform e

      See identical proteins and their annotated locations for NP_001120736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal 12 nt segment, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e) has a shorter and different N-terminus, and lacks internal 4 aa, as compared to isoform a.
      Source sequence(s)
      AK048623, AK137253, BC090649
      Consensus CDS
      CCDS49811.1
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q3UVI3, Q5CZX0
      Related
      ENSMUSP00000110961.1, OTTMUSP00000023060, ENSMUST00000115306.7, OTTMUST00000049677
      Conserved Domains (3) summary
      cd09572
      Location:445509
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:294333
      P53_tetramer; P53 tetramerisation motif
    7. NM_001127265.1NP_001120737.1  tumor protein 63 isoform h

      See identical proteins and their annotated locations for NP_001120737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is an alternate promoter product; it lacks several 5' and 3' exons and an internal 12 nt segment, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (h, also known as DNp63gamma) has shorter and different N- and C-termini, and lacks internal 4 aa, as compared to isoform a.
      Source sequence(s)
      AF075437, AK048623, AK140023, BC092537
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q569E5
      Conserved Domains (2) summary
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:294333
      P53_tetramer; P53 tetramerisation motif
    8. NM_011641.2NP_035771.1  tumor protein 63 isoform d

      See identical proteins and their annotated locations for NP_035771.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as DNp63alpha) has a shorter and different N-terminus, as compared to isoform a.
      Source sequence(s)
      AF075439, AK048623, BC090649
      Consensus CDS
      CCDS28085.1
      UniProtKB/Swiss-Prot
      O88898
      UniProtKB/TrEMBL
      Q5CZX0
      Related
      ENSMUSP00000038117.6, OTTMUSP00000023059, ENSMUST00000040231.12, OTTMUST00000049676
      Conserved Domains (4) summary
      cd09572
      Location:449513
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam00870
      Location:69264
      P53; P53 DNA-binding domain
      pfam07710
      Location:298337
      P53_tetramer; P53 tetramerisation motif
      pfam08430
      Location:363440
      Forkhead_N; Forkhead N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      25683763..25892088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522000.2XP_006522063.1  tumor protein 63 isoform X1

      Conserved Domains (4) summary
      cd09572
      Location:539603
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:388427
      P53_tetramer; P53 tetramerisation motif
      pfam08430
      Location:448531
      Forkhead_N; Forkhead N-terminal region
    2. XM_006522002.1XP_006522065.1  tumor protein 63 isoform X3

      Conserved Domains (2) summary
      pfam00870
      Location:163358
      P53; P53 DNA-binding domain
      pfam07710
      Location:392431
      P53_tetramer; P53 tetramerisation motif
    3. XM_006522001.3XP_006522064.1  tumor protein 63 isoform X2

      Conserved Domains (5) summary
      cd09572
      Location:424488
      SAM_tumor-p63; SAM domain of tumor-p63 proteins
      smart00454
      Location:422487
      SAM; Sterile alpha motif
      pfam08430
      Location:333415
      Forkhead_N; Forkhead N-terminal region
      pfam00870
      Location:44239
      P53; P53 DNA-binding domain
      pfam07710
      Location:272312
      P53_tetramer; P53 tetramerization motif
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