Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Alox5 arachidonate 5-lipoxygenase [ Mus musculus (house mouse) ]

    Gene ID: 11689, updated on 25-May-2017
    Official Symbol
    Alox5provided by MGI
    Official Full Name
    arachidonate 5-lipoxygenaseprovided by MGI
    Primary source
    MGI:MGI:87999
    See related
    Ensembl:ENSMUSG00000025701 Vega:OTTMUSG00000036516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5LO; 5LX; 5-LO; 5-LOX; AI850497; F730011J02
    Orthologs
    Location:
    6 E3; 6 53.79 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (116410071..116461178, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (116360089..116411196, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene membrane-associated ring finger (C3HC4) 8 Neighboring gene predicted gene, 38880 Neighboring gene olfactory receptor 211 Neighboring gene olfactory receptor 212

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    arachidonate 5-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    leukotriene metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    arachidonate 5-lipoxygenase
    Names
    5-lipoxygenase
    NP_033792.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009662.2NP_033792.1  arachidonate 5-lipoxygenase

      See identical proteins and their annotated locations for NP_033792.1

      Status: VALIDATED

      Source sequence(s)
      AK171413, BY205433, BY555055
      Consensus CDS
      CCDS20452.1
      UniProtKB/Swiss-Prot
      P48999
      Related
      ENSMUSP00000026795.6, OTTMUSP00000051997, ENSMUST00000026795.12, OTTMUST00000093640
      Conserved Domains (2) summary
      cd01753
      Location:2115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:224665
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      116410071..116461178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center