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    Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 [ Mus musculus (house mouse) ]

    Gene ID: 108138, updated on 15-May-2017
    Official Symbol
    Xrcc4provided by MGI
    Official Full Name
    X-ray repair complementing defective repair in Chinese hamster cells 4provided by MGI
    Primary source
    MGI:MGI:1333799
    See related
    Ensembl:ENSMUSG00000021615 Vega:OTTMUSG00000035049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW413319; AW545101; 2310057B22Rik
    Orthologs
    Location:
    13; 13 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (89848914..90089608, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (89988519..90229213, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene Neighboring gene versican Neighboring gene uncharacterized LOC108168105 Neighboring gene predicted gene 4117 Neighboring gene transmembrane protein 167 Neighboring gene predicted gene, 41013

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 3' overhang single-stranded DNA endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA ligation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligation involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    immunoglobulin V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protection from non-homologous end joining at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomeric DNA-containing double minutes formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA ligase IV complex ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-dependent protein kinase-DNA ligase 4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-dependent protein kinase-DNA ligase 4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    ERCC4-ERCC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    DNA repair protein XRCC4
    Names
    X-ray repair cross-complementing protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028012.4NP_082288.1  DNA repair protein XRCC4

      See identical proteins and their annotated locations for NP_082288.1

      Status: VALIDATED

      Source sequence(s)
      AK009951, AW455986, BY774472
      Consensus CDS
      CCDS26673.1
      UniProtKB/Swiss-Prot
      Q924T3
      UniProtKB/TrEMBL
      A0A0R4J024
      Related
      ENSMUSP00000022115.7, OTTMUSP00000048674, ENSMUST00000022115.13, OTTMUST00000089147
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      89848914..90089608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517043.3XP_006517106.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517106.1

      UniProtKB/Swiss-Prot
      Q924T3
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    2. XM_006517041.3XP_006517104.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517104.1

      UniProtKB/Swiss-Prot
      Q924T3
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    3. XM_006517042.2XP_006517105.1  DNA repair protein XRCC4 isoform X1

      See identical proteins and their annotated locations for XP_006517105.1

      UniProtKB/Swiss-Prot
      Q924T3
      UniProtKB/TrEMBL
      A0A0R4J024
      Conserved Domains (1) summary
      pfam06632
      Location:2326
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
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