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    Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14056, updated on 17-Sep-2017
    Official Symbol
    Ezh2provided by MGI
    Official Full Name
    enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:107940
    See related
    Ensembl:ENSMUSG00000029687 Vega:OTTMUSG00000021193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT6; Enx-1; Enx1h; mKIAA4065
    Orthologs
    Location:
    6 B2.3; 6 22.92 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (47530274..47595340, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47480273..47545029, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene cullin 1 Neighboring gene predicted gene, 40371 Neighboring gene predicted gene, 40369 Neighboring gene 4.5S RNA

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4065, MGC90723

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase activity (H3-K27 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to trichostatin A IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone H3-K27 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K27 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K27 trimethylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    immunoglobulin heavy chain V-D-J recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    liver regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to tetrachloromethane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    histone-lysine N-methyltransferase EZH2
    Names
    enhancer of zeste homolog 2
    NP_001140161.1
    NP_031997.2
    XP_006505583.1
    XP_006505584.1
    XP_006505586.1
    XP_006505587.1
    XP_006505588.1
    XP_006505589.1
    XP_006505590.1
    XP_006505591.1
    XP_006505592.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146689.1NP_001140161.1  histone-lysine N-methyltransferase EZH2 isoform 2

      See identical proteins and their annotated locations for NP_001140161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS51760.1
      UniProtKB/TrEMBL
      Q3TZH6, Q571L5, Q6AXH7
      Related
      ENSMUSP00000110265.1, OTTMUSP00000023408, ENSMUST00000114618.7, OTTMUST00000050209
      Conserved Domains (2) summary
      smart00317
      Location:608729
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    2. NM_007971.2NP_031997.2  histone-lysine N-methyltransferase EZH2 isoform 1

      See identical proteins and their annotated locations for NP_031997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as ENX-1A.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS20096.1
      UniProtKB/Swiss-Prot
      Q61188
      UniProtKB/TrEMBL
      Q3TZH6, Q571L5, Q6AXH7
      Related
      ENSMUSP00000080419.6, OTTMUSP00000023406, ENSMUST00000081721.12, OTTMUST00000050207
      Conserved Domains (2) summary
      smart00317
      Location:612733
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      47530274..47595340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505521.2XP_006505584.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505584.1

      Conserved Domains (2) summary
      smart00317
      Location:617738
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    2. XM_006505526.3XP_006505589.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505589.1

      Conserved Domains (2) summary
      smart00317
      Location:617738
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    3. XM_006505525.1XP_006505588.1  histone-lysine N-methyltransferase EZH2 isoform X4

      Conserved Domains (2) summary
      smart00317
      Location:561682
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    4. XM_006505523.1XP_006505586.1  histone-lysine N-methyltransferase EZH2 isoform X2

      Conserved Domains (2) summary
      smart00317
      Location:603724
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    5. XM_006505524.1XP_006505587.1  histone-lysine N-methyltransferase EZH2 isoform X3

      Related
      ENSMUSP00000090318.6, OTTMUSP00000050434, ENSMUST00000092648.12, OTTMUST00000091541
      Conserved Domains (2) summary
      smart00317
      Location:575696
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    6. XM_006505529.1XP_006505592.1  histone-lysine N-methyltransferase EZH2 isoform X6

      Conserved Domains (1) summary
      smart00317
      Location:375496
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    7. XM_006505527.1XP_006505590.1  histone-lysine N-methyltransferase EZH2 isoform X5

      See identical proteins and their annotated locations for XP_006505590.1

      Conserved Domains (1) summary
      smart00317
      Location:380501
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    8. XM_006505520.3XP_006505583.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505583.1

      Conserved Domains (2) summary
      smart00317
      Location:617738
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    9. XM_006505528.1XP_006505591.1  histone-lysine N-methyltransferase EZH2 isoform X5

      See identical proteins and their annotated locations for XP_006505591.1

      Conserved Domains (1) summary
      smart00317
      Location:380501
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
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