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    Hprt hypoxanthine guanine phosphoribosyl transferase [ Mus musculus (house mouse) ]

    Gene ID: 15452, updated on 6-Dec-2016
    Official Symbol
    Hprtprovided by MGI
    Official Full Name
    hypoxanthine guanine phosphoribosyl transferaseprovided by MGI
    Primary source
    MGI:MGI:96217
    See related
    Ensembl:ENSMUSG00000025630 Vega:OTTMUSG00000017356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HPGRT; Hprt1; C81579
    Summary
    The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    X A5; X 29.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (52988078..53021660)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (50341255..50374837)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 13 Neighboring gene PHD finger protein 6 Neighboring gene microRNA 450-1 Neighboring gene microRNA 450b

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC103149

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    guanine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hypoxanthine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypoxanthine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adenine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenine salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    grooming behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT grooming behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    guanine salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    guanine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    hypoxanthine metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    hypoxanthine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypoxanthine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hypoxanthine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    purine ribonucleoside salvage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    purine ribonucleoside salvage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    purine ribonucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striatum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    hypoxanthine-guanine phosphoribosyltransferase
    Names
    HGPRT
    HGPRTase
    HPRT B
    hypoxanthine guanine phosphoribosyl transferase 1
    NP_038584.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013556.2NP_038584.2  hypoxanthine-guanine phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_038584.2

      Status: REVIEWED

      Source sequence(s)
      AK002286, AK146626, BY285280
      Consensus CDS
      CCDS40972.1
      UniProtKB/Swiss-Prot
      P00493
      Related
      ENSMUSP00000026723, OTTMUSP00000018945, ENSMUST00000026723, OTTMUST00000042141
      Conserved Domains (1) summary
      cl00309
      Location:6218
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      52988078..53021660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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