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    NR1H3 nuclear receptor subfamily 1 group H member 3 [ Homo sapiens (human) ]

    Gene ID: 10062, updated on 15-Oct-2017
    Official Symbol
    NR1H3provided by HGNC
    Official Full Name
    nuclear receptor subfamily 1 group H member 3provided by HGNC
    Primary source
    HGNC:HGNC:7966
    See related
    Ensembl:ENSG00000025434 MIM:602423; Vega:OTTHUMG00000150628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LXRA; LXR-a; RLD-1
    Summary
    The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Orthologs
    Location:
    11p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (47248300..47269033)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47269851..47290584)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 26 Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene uncharacterized LOC101928943 Neighboring gene MAP kinase activating death domain Neighboring gene myosin binding protein C, cardiac

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
    NHGRI GWA Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA activates NR1H3 signaling in primary hepatocytes PubMed
    gag HIV-1 MA upregulates NR1H3 mRNA expression in HepG2 cells and primary hepatocytes PubMed
    gag HIV-1 MA upregulates NR1H3 (LXR-alpha) gene expresssion in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    cholesterol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    sterol response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cholesterol storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interferon-gamma-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of pancreatic juice secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of secretion of lysosomal enzymes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipoprotein lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    sterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    oxysterols receptor LXR-alpha
    Names
    liver X nuclear receptor alpha variant 1
    NP_001123573.1
    NP_001123574.1
    NP_001238863.1
    NP_001238864.1
    NP_005684.2
    XP_005252762.1
    XP_005252763.1
    XP_005252764.1
    XP_005252766.1
    XP_005252767.1
    XP_005252770.1
    XP_005252772.1
    XP_005252773.1
    XP_005252775.1
    XP_006718175.1
    XP_006718176.1
    XP_006718178.1
    XP_006718179.1
    XP_011518107.1
    XP_011518108.1
    XP_011518109.1
    XP_011518110.1
    XP_016872545.1
    XP_016872546.1
    XP_016872547.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030392.1 RefSeqGene

      Range
      5001..25734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130101.2NP_001123573.1  oxysterols receptor LXR-alpha isoform 2

      See identical proteins and their annotated locations for NP_001123573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AA644385, AI097478, AU133574, BC008819
      Consensus CDS
      CCDS44584.1
      UniProtKB/Swiss-Prot
      Q13133
      Related
      ENSP00000384745.3, OTTHUMP00000198041, ENST00000405853.7, OTTHUMT00000319219
      Conserved Domains (2) summary
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:210385
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001130102.2NP_001123574.1  oxysterols receptor LXR-alpha isoform 3

      See identical proteins and their annotated locations for NP_001123574.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA644385, AI097478, AU135617, BC041172
      Consensus CDS
      CCDS44585.1
      UniProtKB/Swiss-Prot
      Q13133
      Related
      ENSP00000378793.3, OTTHUMP00000234325, ENST00000395397.7, OTTHUMT00000391716
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    3. NM_001251934.1NP_001238863.1  oxysterols receptor LXR-alpha isoform 4

      See identical proteins and their annotated locations for NP_001238863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.
      Source sequence(s)
      AA644385, AI097478, AK302132, AK311590
      Consensus CDS
      CCDS73285.1
      UniProtKB/TrEMBL
      B4DXU5
      Conserved Domains (2) summary
      cd06954
      Location:216451
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:84184
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    4. NM_001251935.1NP_001238864.1  oxysterols receptor LXR-alpha isoform 4

      See identical proteins and their annotated locations for NP_001238864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform (4).
      Source sequence(s)
      AA644385, AI097478, AK302132, AK311590
      Consensus CDS
      CCDS73285.1
      UniProtKB/TrEMBL
      B4DXU5
      Related
      ENSP00000477707.1, ENST00000616973.4
      Conserved Domains (2) summary
      cd06954
      Location:216451
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:84184
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    5. NM_005693.3NP_005684.2  oxysterols receptor LXR-alpha isoform 1

      See identical proteins and their annotated locations for NP_005684.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AA644385, AI097478, AK290614, AK302132, AU133574
      Consensus CDS
      CCDS7929.1
      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      B4DXU5, F1D8N1
      Related
      ENSP00000387946.2, OTTHUMP00000234328, ENST00000441012.6, OTTHUMT00000391718
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      47248300..47269033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252718.3XP_005252775.1  oxysterols receptor LXR-alpha isoform X9

      Conserved Domains (1) summary
      cl11397
      Location:76251
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_005252716.3XP_005252773.1  oxysterols receptor LXR-alpha isoform X6

      See identical proteins and their annotated locations for XP_005252773.1

      Conserved Domains (1) summary
      cd06954
      Location:76311
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    3. XM_011519808.2XP_011518110.1  oxysterols receptor LXR-alpha isoform X10

      Conserved Domains (1) summary
      cd06954
      Location:1233
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    4. XM_005252713.3XP_005252770.1  oxysterols receptor LXR-alpha isoform X7

      See identical proteins and their annotated locations for XP_005252770.1

      UniProtKB/Swiss-Prot
      Q13133
      Related
      ENSP00000385801.1, OTTHUMP00000198038, ENST00000407404.5, OTTHUMT00000319215
      Conserved Domains (2) summary
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:210385
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_011519805.2XP_011518107.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_011518107.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    6. XM_006718113.1XP_006718176.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_006718176.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    7. XM_005252706.1XP_005252763.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_005252763.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    8. XM_017017058.1XP_016872547.1  oxysterols receptor LXR-alpha isoform X5

      UniProtKB/Swiss-Prot
      Q13133
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    9. XM_005252705.1XP_005252762.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_005252762.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    10. XM_005252709.1XP_005252766.1  oxysterols receptor LXR-alpha isoform X5

      See identical proteins and their annotated locations for XP_005252766.1

      UniProtKB/Swiss-Prot
      Q13133
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    11. XM_006718116.1XP_006718179.1  oxysterols receptor LXR-alpha isoform X5

      See identical proteins and their annotated locations for XP_006718179.1

      UniProtKB/Swiss-Prot
      Q13133
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    12. XM_006718112.1XP_006718175.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_006718175.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    13. XM_005252707.4XP_005252764.1  oxysterols receptor LXR-alpha isoform X1

      See identical proteins and their annotated locations for XP_005252764.1

      UniProtKB/Swiss-Prot
      Q13133
      UniProtKB/TrEMBL
      F1D8N1
      Related
      ENSP00000420656.1, OTTHUMP00000198037, ENST00000467728.5, OTTHUMT00000319214
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    14. XM_006718115.1XP_006718178.1  oxysterols receptor LXR-alpha isoform X5

      See identical proteins and their annotated locations for XP_006718178.1

      UniProtKB/Swiss-Prot
      Q13133
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    15. XM_005252715.2XP_005252772.1  oxysterols receptor LXR-alpha isoform X8

      See identical proteins and their annotated locations for XP_005252772.1

      Conserved Domains (1) summary
      cd06954
      Location:121356
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    16. XM_011519807.1XP_011518109.1  oxysterols receptor LXR-alpha isoform X6

      See identical proteins and their annotated locations for XP_011518109.1

      Conserved Domains (1) summary
      cd06954
      Location:76311
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    17. XM_011519806.1XP_011518108.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/TrEMBL
      B5MBY7
      Related
      ENSP00000385073.1, OTTHUMP00000198039, ENST00000405576.5, OTTHUMT00000319216
      Conserved Domains (2) summary
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:165340
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    18. XM_017017056.1XP_016872545.1  oxysterols receptor LXR-alpha isoform X3

    19. XM_017017057.1XP_016872546.1  oxysterols receptor LXR-alpha isoform X4

    20. XM_005252710.1XP_005252767.1  oxysterols receptor LXR-alpha isoform X5

      See identical proteins and their annotated locations for XP_005252767.1

      UniProtKB/Swiss-Prot
      Q13133
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      47268541..47289773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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