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    FAP fibroblast activation protein alpha [ Homo sapiens (human) ]

    Gene ID: 2191, updated on 11-Jun-2017
    Official Symbol
    FAPprovided by HGNC
    Official Full Name
    fibroblast activation protein alphaprovided by HGNC
    Primary source
    HGNC:HGNC:3590
    See related
    Ensembl:ENSG00000078098 MIM:600403; Vega:OTTHUMG00000153890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAPA; SIMP; DPPIV; FAPalpha
    Summary
    The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    2q24.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (162170684..162243535, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (163027194..163100045, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit E pseudogene 2 Neighboring gene uncharacterized LOC101929532 Neighboring gene glucagon Neighboring gene uncharacterized LOC105373724 Neighboring gene interferon induced with helicase C domain 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686G13158

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dipeptidyl-peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serine-type peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    melanocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation involved in contact inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of extracellular matrix disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of fibrinolysis IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    basal part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    invadopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ruffle membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    prolyl endopeptidase FAP
    Names
    170 kDa melanoma membrane-bound gelatinase
    dipeptidyl peptidase FAP
    gelatine degradation protease FAP
    integral membrane serine protease
    post-proline cleaving enzyme
    seprase
    surface-expressed protease
    NP_001278736.1
    NP_004451.2
    XP_011509098.1
    XP_011509099.1
    XP_016859074.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027991.1 RefSeqGene

      Range
      4979..77852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291807.2NP_001278736.1  prolyl endopeptidase FAP isoform 2

      See identical proteins and their annotated locations for NP_001278736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK297118, AL832166, DA655829, U09278
      Consensus CDS
      CCDS77480.1
      UniProtKB/Swiss-Prot
      Q12884
      UniProtKB/TrEMBL
      B4DLR2
      Related
      ENSP00000411391.1, OTTHUMP00000207304, ENST00000443424.5, OTTHUMT00000338544
      Conserved Domains (2) summary
      pfam00326
      Location:528734
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:89448
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. NM_004460.4NP_004451.2  prolyl endopeptidase FAP isoform 1

      See identical proteins and their annotated locations for NP_004451.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL832166, BC026250, DA655829, U09278
      Consensus CDS
      CCDS33311.1
      UniProtKB/Swiss-Prot
      Q12884
      Related
      ENSP00000188790.4, OTTHUMP00000204566, ENST00000188790.8, OTTHUMT00000332852
      Conserved Domains (2) summary
      pfam00326
      Location:553759
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      162170684..162243535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510796.2XP_011509098.1  prolyl endopeptidase FAP isoform X1

      Conserved Domains (2) summary
      pfam00326
      Location:543749
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:96463
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. XM_011510797.2XP_011509099.1  prolyl endopeptidase FAP isoform X2

      Conserved Domains (1) summary
      pfam00930
      Location:106473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    3. XM_017003585.1XP_016859074.1  prolyl endopeptidase FAP isoform X3

    RNA

    1. XR_001738668.1 RNA Sequence

    2. XR_922891.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      163033084..163105931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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