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    Ptprc protein tyrosine phosphatase, receptor type, C [ Mus musculus (house mouse) ]

    Gene ID: 19264, updated on 8-Nov-2017
    Official Symbol
    Ptprcprovided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, Cprovided by MGI
    Primary source
    MGI:MGI:97810
    See related
    Ensembl:ENSMUSG00000026395 Vega:OTTMUSG00000043098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
    Orthologs
    Location:
    1 E4; 1 60.73 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (138062859..138175756, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (139959438..140071882, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 181b-1 Neighboring gene predicted gene, 34353 Neighboring gene PAP associated domain containing 4 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
      EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone marrow development ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immunoglobulin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell adhesion involved in substrate-bound cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of antigen receptor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hematopoietic stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    leukocyte common antigen
    lymphocyte antigen 5
    lymphocyte common antigen
    NP_001104786.2
    NP_001255215.1
    NP_035340.3
    XP_006529320.1
    XP_006529321.1
    XP_006529322.1
    XP_006529323.1
    XP_006529324.1
    XP_006529325.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111316.2NP_001104786.2  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001104786.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122903, AC159278, AK054056, BM239381, CA575153, CA577897, CK392851
      Consensus CDS
      CCDS48383.2
      UniProtKB/TrEMBL
      Q8C6Q7, S4R1S4
      Conserved Domains (5) summary
      smart00194
      Location:641900
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:669900
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:474553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:212265
      CD45; Leukocyte receptor CD45
    2. NM_001268286.1NP_001255215.1  receptor-type tyrosine-protein phosphatase C precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC122903, AK054056, BM239381, CA575153, CA577897
      Consensus CDS
      CCDS59542.1
      UniProtKB/TrEMBL
      Q8C6Q7, S4R1M0
      Related
      ENSMUSP00000138275.1, OTTMUSP00000063322, ENSMUST00000182755.7, OTTMUST00000113096
      Conserved Domains (5) summary
      smart00194
      Location:478737
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:506737
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:311390
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:49102
      CD45; Leukocyte receptor CD45
    3. NM_011210.4NP_035340.3  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

      See identical proteins and their annotated locations for NP_035340.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122903, AK054056, BM239381, CA575153, CA577897
      Consensus CDS
      CCDS15330.2
      UniProtKB/TrEMBL
      Q8C6Q7, S4R2V1
      Related
      ENSMUSP00000138800.1, OTTMUSP00000063321, ENSMUST00000182283.7, OTTMUST00000113095
      Conserved Domains (5) summary
      smart00194
      Location:502761
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:530761
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:335414
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:73126
      CD45; Leukocyte receptor CD45

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      138062859..138175756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529258.3XP_006529321.1  receptor-type tyrosine-protein phosphatase C isoform X1

      See identical proteins and their annotated locations for XP_006529321.1

      UniProtKB/TrEMBL
      S4R1S4
      Conserved Domains (5) summary
      smart00194
      Location:641900
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:669900
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:474553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:212265
      CD45; Leukocyte receptor CD45
    2. XM_006529259.3XP_006529322.1  receptor-type tyrosine-protein phosphatase C isoform X1

      See identical proteins and their annotated locations for XP_006529322.1

      UniProtKB/TrEMBL
      S4R1S4
      Conserved Domains (5) summary
      smart00194
      Location:641900
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:669900
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:474553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:212265
      CD45; Leukocyte receptor CD45
    3. XM_006529262.3XP_006529325.1  receptor-type tyrosine-protein phosphatase C isoform X4

      Conserved Domains (5) summary
      smart00194
      Location:551810
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:579810
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:384463
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:122175
      CD45; Leukocyte receptor CD45
    4. XM_006529260.1XP_006529323.1  receptor-type tyrosine-protein phosphatase C isoform X2

      Conserved Domains (5) summary
      smart00194
      Location:598857
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:626857
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:431510
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:169222
      CD45; Leukocyte receptor CD45
    5. XM_006529261.3XP_006529324.1  receptor-type tyrosine-protein phosphatase C isoform X3

      Conserved Domains (5) summary
      smart00194
      Location:594853
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:622853
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:427506
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:165218
      CD45; Leukocyte receptor CD45
    6. XM_006529257.1XP_006529320.1  receptor-type tyrosine-protein phosphatase C isoform X1

      See identical proteins and their annotated locations for XP_006529320.1

      UniProtKB/TrEMBL
      S4R1S4
      Related
      ENSMUSP00000138350.1, OTTMUSP00000063320, ENSMUST00000183301.7, OTTMUST00000113094
      Conserved Domains (5) summary
      smart00194
      Location:641900
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:669900
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:474553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:731
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:212265
      CD45; Leukocyte receptor CD45
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